Barrier island overwash occurs when the elevation of wave runup exceeds the dune crest and induces landward transport of sediment across a barrier island and deposition of a washover deposit. Washover deposition is generally attributed to major storms, is important for the maintenance of barrier island resilience to sea-level rise and is used to extend hurricane records beyond historical accounts by reconstructing the frequency and extent of washover deposits preserved in the sedimentary record. Here, we present a high-fidelity 3-year record of washover evolution and overwash at a transgressive barrier island site. During the first year after establishment, washover volume and area increased 1595% and 197%, respectively, from at least monthly overwash. Most of the washover accretion resulted from the site morphology having a low resistance to overwash, as opposed to being directly impacted by major storms. Washover deposits can accrete landward over multi-year time scales in the absence of large storms; therefore, paleotempestites can be more complex than single event beds.Photoplethysmography (PPG) measured by smartphone has the potential for a large scale, non-invasive, and easy-to-use screening tool. https://www.selleckchem.com/products/triparanol-mer-29.html Vascular aging is linked to increased arterial stiffness, which can be measured by PPG. We investigate the feasibility of using PPG to predict healthy vascular aging (HVA) based on two approaches machine learning (ML) and deep learning (DL). We performed data preprocessing, including detrending, demodulating, and denoising on the raw PPG signals. For ML, ridge penalized regression has been applied to 38 features extracted from PPG, whereas for DL several convolutional neural networks (CNNs) have been applied to the whole PPG signals as input. The analysis has been conducted using the crowd-sourced Heart for Heart data. The prediction performance of ML using two features (AUC of 94.7%) - the a wave of the second derivative PPG and tpr, including four covariates, sex, height, weight, and smoking - was similar to that of the best performing CNN, 12-layer ResNet (AUC of 95.3%). Without having the heavy computational cost of DL, ML might be advantageous in finding potential biomarkers for HVA prediction. The whole workflow of the procedure is clearly described, and open software has been made available to facilitate replication of the results.Urinary incontinence of idiopathic nature is a common complication of bladder cancer, yet, the mechanisms underlying changes in bladder contractility associated with cancer are not known. Here by using tensiometry on detrusor smooth muscle (DSM) strips from normal rats and rats with bladder cancer induced by known urothelial carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), we show that bladder cancer is associated with considerable changes in DSM contractility. These changes include (1) decrease in the amplitude and frequency of spontaneous contractions, consistent with the decline of luminal pressures during filling, and detrusor underactivity; (2) diminution of parasympathetic DSM stimulation mainly at the expense of m-cholinergic excitatory transmission, suggestive of difficulty in bladder emptying and weakening of urine stream; (3) strengthening of TRPV1-dependent afferent limb of micturition reflex and TRPV1-mediated local contractility, promoting urge incontinence; (4) attenuation of stretch-dependent, TRPV4-mediated spontaneous contractility leading to overflow incontinence. These changes are consistent with the symptomatic of bladder dysfunction in bladder cancer patients. Considering that BBN-induced urothelial lesions in rodents largely resemble human urothelial lesions at least in their morphology, our studies establish for the first time underlying reasons for bladder dysfunction in bladder cancer.Amphibian larvae are plastic organisms that can adjust their growth and developmental rates to local environmental conditions. The consequences of such developmental alterations have been studied in detail, both at the phenotypic and physiological levels. While largely unknown, it is of great importance to assess how developmental alterations affect the pigmentation pattern of the resulting metamorphs, because pigmentation is relevant for communication, mate choice, and camouflage and hence influences the overall fitness of the toads. Here we quantify the variation in several aspects of the pigmentation pattern of juvenile spadefoot toads experimentally induced to accelerate their larval development in response to decreased water level. It is known that induced developmental acceleration comes at the cost of reduced size at metamorphosis, higher metabolic rate, and increased oxidative stress. In this study, we show that spadefoot toads undergoing developmental acceleration metamorphosed with a less complex, more homogeneous, darker dorsal pattern consisting of continuous blotches, compared to the more contrasted pattern with segregated blotches and higher fractal dimension in normally developing individuals, and at a smaller size. We also observed a marked effect of population of origin in the complexity of the pigmentation pattern. Complexity of the post-metamorphic dorsal pigmentation could therefore be linked to pre-metamorphic larval growth and development.Micro-grooves are a crucial feature in many applications, such as microelectro-mechanical systems, drug delivery, heat pipes, sorption systems, and microfluidic devices. Micro-grooves utilize capillary action to deliver a liquid, with no need for an extra pumping device, which makes them unique and desirable for numerous systems. Although the capillary action is well studied, all the available equations for the capillary rise are case-specific and depend on the geometry of the groove, surface properties, and the transport liquid. In this study, a unified non-dimensional model for capillary rise is proposed that can accurately predict the capillary rise for any given groove geometry and condition and only depends on two parameters contact angle and characteristic length scale, defined as the ratio of the liquid-vapor to the solid-liquid interface. The proposed model is compared against data from the literature and can capture the experimental results with less than 10% relative difference. The effect of the grooves' height, width, and contact angle is investigated and reported.