Published by BMJ.Glomus tumour is uncommon benign tumour, which derives from the glomus cells present around arteriovenous anastomosis. These tumours are found most commonly in the deep dermis of the extremities. Primary pulmonary glomus tumour is extremely rare and often misdiagnosed. Knowledge about the existence of glomus tumour in the lung, its classic histomorphology and judicious use of immunohistochemistry can help us in clinching the correct diagnosis. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.A 64-year-old hypertensive woman presented with complaints of a painless, progressive decrease in vision, headache, dizziness for the last month. She was a known case of diabetes mellitus on insulin therapy. On examination, best-corrected visual acuity was 6/12 in the right eye and 6/18 in the left eye. The fundus examination in both eyes revealed features of grade IV hypertensive retinopathy. Systemic examination revealed the raised blood pressure of 200/110 mm Hg. Diagnosis of pheochromocytoma was made on the basis of increased urinary norepinephrine (892.8 mg/dL) and mass in the left adrenal gland (measuring 31×28 mm) at contrast-enhanced CT. Medical management to control hypertension was done and ultimately, she underwent left laparoscopic adrenalectomy. After 10 months of surgery, the patient was asymptomatic, blood pressure was within normal limit and her vision improved to 6/6 in both the eyes. The retinal features of hypertensive retinopathy had completely disappeared. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.Takotsubo syndrome is increasingly recognised worldwide. As both, takotsubo syndrome and acute myocardial infarction can present with similar findings, including chest pain, elevated troponin and creatine kinase, it is often difficult to differentiate these conditions. Here, we present a challenging case that illustrates (1) difficulties to diagnose takotsubo syndrome in the presence of a significant coronary artery stenosis; (2) how takotsubo syndrome could be misdiagnosed as acute coronary syndrome if diagnostic workup does not include echocardiography or left ventriculography; (3) the importance of cardiac MRI which can contribute to the diagnosis of takotsubo syndrome. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.We report a retroviral positive patient who presented to us with recurrent skin lesions along with intermittent, colicky periumbilical abdominal pain associated with non-projectile, postprandial vomiting. Contrast-enhanced CT (CECT) of abdomen and pelvis was suggestive of proximal jejunal obstruction. Double balloon enteroscopy done which showed extensive deep ulceration with surrounding nodular surface and friable mucosa at 60 cm from pylorus with luminal narrowing. The biopsy from this region as well as the skin lesion on the forehead grew Talaromyces marneffei She was initially treated with liposomal amphotericin B for 2 weeks following which she received itraconazole for 3 weeks for disseminated talaromycosis infection. https://www.selleckchem.com/products/resatorvid.html She had already been started on antiretroviral therapy (ART) 1 year back however her cluster of differentiation 4 (CD4) counts did not show any improvement. Proximal bowel obstruction leading to poor nutritional status compounded with ineffective ART therapy due to suboptimal absorption, dictated the staged management of her condition. Feeding jejunostomy was done with a plan to offer her resection and anastomosis of affected jejunal segment, should she require one, after optimising her nutritional and immunological status. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.PURPOSE If routine diagnostics are inconclusive, neurological deterioration and death of brain cancer patients are attributed to tumor or therapy. Therefore, diagnosing symptoms of encephalopathy caused by human-cytomegalovirus-(HCMV)-reactivation remains uncommon. We investigated the role of HCMV-reactivation in neurological decline and clinical outcome after the start of radiochemotherapy. EXPERIMENTAL DESIGN HCMV-analyses and extended MRI-studies including additional independent retrospective neuroradiological evaluation were performed at predetermined intervals and in case of sudden neurological decline for 118 adult patients 63 histologically proven high-grade gliomas, 55 with brain metastases. Immunophenotyping from simultaneously taken whole blood samples was carried out to detect immune cells serving as prognostic marker for HCMV-associated complications. ENDPOINTS symptomatic viremia, overall survival (OS). RESULTS 24% (28/118) of all patients (12/44 glioblastoma, 3/13 anaplastic astrocytoma; 8/31 nor Cancer Research.Members of the scientific and clinical neuro-oncology community met in April 2019 to discuss the current challenges and opportunities associated with translating basic science discoveries in glioblastoma to improved survival for patients. A summary of key points of these discussions is presented in this report. Copyright ©2020, American Association for Cancer Research.PURPOSE The tumor microenvironment (TME) consists of a heterogenous cellular milieu that can influence cancer cell behavior. Its characteristics havean impact on treatments such as immunotherapy. These features can be revealed with single-cell RNA sequencing (scRNA-seq). We hypothesized that scRNA-seq analysis ofgastric cancer (GC) together with paired normal tissue and peripheral blood mononuclear cells (PBMCs) would identify critical elements of cellular deregulation not apparent with other approaches. EXPERIMENTAL DESIGN scRNA-seq was conducted on seven patients with GC and one patient with intestinal metaplasia. We sequenced 56,167 cells comprising GC (32,407 cells), paired normal tissue (18,657 cells) and PBMCs (5,103 cells). Protein expression was validated by multiplex immunofluorescence. RESULTS Tumor epithelium had copy number alterations, a distinct gene expression program from normal, with intra-tumor heterogeneity. GC TME was significantly enriched for stromal cells, macrophages, dendritic cells (DCs) and Tregs.