ELANE Protein: A Dual-Edged Regulator of Inflammation, Immunity,...

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2025-08-04 05:57:42 -

ELANE Protein: A Dual-Edged Regulator of Inflammation, Immunity, and Tissue Remodeling

ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when...

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