Discovery and Mechanism of ActionIt was first synthesized in the 1930s as a combination of sulfapyridine, an antibacterial sulfonamide antibiotic, and 5-aminosalicylic acid (5-ASA). Early clinical trials in the 1940s found that it was effective for treating ulcerative colitis. However, its exact mechanism of action for treating inflammatory bowel disease (IBD) was not fully understood until...
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