Finally, we show that long simulations of a smaller model with complex stimuli and a custom three-factor learning rule defined in PyGeNN can be simulated almost two orders of magnitude faster than real-time.The cerebral cortex is fundamental to the functioning of the mind and body. In vivo cortical morphology can be studied through magnetic resonance imaging in several ways, including reconstructing surface-based models of the cortex. However, existing software for surface-based statistical analyses cannot accommodate "big data" or commonly used statistical methods such as the imputation of missing data, extensive bias correction, and non-linear modeling. To address these shortcomings, we developed the QDECR package, a flexible and extensible R package for group-level statistical analysis of cortical morphology. QDECR was written with large population-based epidemiological studies in mind and was designed to fully utilize the extensive modeling options in R. QDECR currently supports vertex-wise linear regression. Design matrix generation can be done through simple, familiar R formula specification, and includes user-friendly extensions for R options such as polynomials, splines, interactions and other terms. QDECR can handle unimputed and imputed datasets with thousands of participants. QDECR has a modular design, and new statistical models can be implemented which utilize several aspects from other generic modules which comprise QDECR. In summary, QDECR provides a framework for vertex-wise surface-based analyses that enables flexible statistical modeling and features commonly used in population-based and clinical studies, which have until now been largely absent from neuroimaging research.One of the most fundamental questions in the field of neuroscience is the emergence of synchronous behaviour in the brain, such as phase, anti-phase, and shift-phase synchronisation. In this work, we investigate how the connectivity between brain areas can influence the phase angle and the neuronal synchronisation. To do this, we consider brain areas connected by means of excitatory and inhibitory synapses, in which the neuron dynamics is given by the adaptive exponential integrate-and-fire model. https://www.selleckchem.com/products/ag-120-Ivosidenib.html Our simulations suggest that excitatory and inhibitory connections from one area to another play a crucial role in the emergence of these types of synchronisation. Thus, in the case of unidirectional interaction, we observe that the phase angles of the neurons in the receiver area depend on the excitatory and inhibitory synapses which arrive from the sender area. Moreover, when the neurons in the sender area are synchronised, the phase angle variability of the receiver area can be reduced for some conductance values between the areas. For bidirectional interactions, we find that phase and anti-phase synchronisation can emerge due to excitatory and inhibitory connections. We also verify, for a strong inhibitory-to-excitatory interaction, the existence of silent neuronal activities, namely a large number of excitatory neurons that remain in silence for a long time.We derive a theoretical construct that allows for the characterisation of both scalable and scale free systems within the dynamic causal modelling (DCM) framework. We define a dynamical system to be "scalable" if the same equation of motion continues to apply as the system changes in size. As an example of such a system, we simulate planetary orbits varying in size and show that our proposed methodology can be used to recover Kepler's third law from the timeseries. In contrast, a "scale free" system is one in which there is no characteristic length scale, meaning that images of such a system are statistically unchanged at different levels of magnification. As an example of such a system, we use calcium imaging collected in murine cortex and show that the dynamical critical exponent, as defined in renormalization group theory, can be estimated in an empirical biological setting. We find that a task-relevant region of the cortex is associated with higher dynamical critical exponents in task vs. spontaneous states and vice versa for a task-irrelevant region.Working memory is closely involved in various cognitive activities, but its neural mechanism is still under exploration. The mainstream view has long been that persistent activity is the neural basis of working memory, but recent experiments have observed that activity-silent memory can also be correctly recalled. The underlying mechanism of activity-silent memory is considered to be an alternative scheme that rejects the theory of persistent activity. We propose a working memory model based on spike-timing-dependent plasticity (STDP). Different from models based on spike-rate coding, our model adopts temporal patterns of action potentials to represent information, so it can flexibly encode new memory representation. The model can work in both persistent and silent states, i.e., it is compatible with both of these seemingly conflicting neural mechanisms. We conducted a simulation experiment, and the results are similar to the real experimental results, which suggests that our model is plausible in biology.In this paper we present a Competitive Rate-Based Algorithm (CRBA) that approximates operation of a Competitive Spiking Neural Network (CSNN). CRBA is based on modeling of the competition between neurons during a sample presentation, which can be reduced to ranking of the neurons based on a dot product operation and the use of a discrete Expectation Maximization algorithm; the latter is equivalent to the spike time-dependent plasticity rule. CRBA's performance is compared with that of CSNN on the MNIST and Fashion-MNIST datasets. The results show that CRBA performs on par with CSNN, while using three orders of magnitude less computational time. Importantly, we show that the weights and firing thresholds learned by CRBA can be used to initialize CSNN's parameters that results in its much more efficient operation.A deep investigation of proprioceptive processes is necessary to understand the relationship between sensory afferent inputs and motor outcomes. In this work, we investigate whether and how perception of wrist position is influenced by the direction along which the movement occurs. Most previous studies have tested Joint Position Sense (JPS) through 1 degree of freedom (DoF) wrist movements, such as flexion/extension (FE) or radial/ulnar deviation (RUD). However, the wrist joint has 3-DoF and many activities of daily living produce combined movements, requiring at least 2-DoF wrist coordination. For this reason, in this study, target positions involved movement directions that combined wrist flexion or extension with radial or ulnar deviation. The chosen task was a robot-aided Joint Position Matching (JPM), in which blindfolded participants actively reproduced a previously passively assumed target joint configuration. The JPM performance of 20 healthy participants was quantified through measures of accuracy and precision, in terms of both perceived target direction and distance along each direction of movement.