Although very recently, David H [...].N-acetylcysteine (NAC) is a pharmacological alternative with great potential for reducing the deleterious effects of surgical procedures on patients with steatohepatitis. We evaluated the effect of NAC on hepatic ischemia/reperfusion (I/R) injury in C57BL/6J mice, 8 weeks-old, weighing 25-30 g, with steatohepatitis induced by a methionine- and choline-deficient (MCD) diet. Groups MCD group (steatohepatitis), MCD-I/R group (steatohepatitis plus 30 min of 70% liver ischemia and 24 h of reperfusion), MCD-I/R+NAC group (same as MCD-I/R group plus 150 mg/kg NAC 15 min before ischemia), and control group (normal AIN-93M diet). Liver enzymes and histopathology; nitrite and TBARS (thiobarbituric acid reactive substances) levels; pro-inflammatory cytokines; antioxidants enzymes; Nrf2 (nuclear factor erythroid-2-related factor 2) expression; and apoptosis were evaluated. In the group treated with NAC, reductions in inflammatory infiltration; AST (aspartate aminotransferase), nitrite, and TBARS levels; GPx (gutathione peroxidase) activity; cytokines synthesis; and number of apoptotic cells were observed while the GR (glutathione reductase) activity was increased. No differences were observed in Nfr2 expression or in SOD (superoxide dismutase), CAT (catalase), and GST (glutathione S-transferase) activities. Thus, it may be concluded that NAC exerts beneficial effects on mice livers with steatohepatitis submitted to I/R by reducing oxidative stress, inflammatory response, and cell death.There are different ways for antibiotics to enter the aquatic environment, with wastewater treatment plants (WWTP) considered to be one of the main points of entrance. Even treated wastewater effluent can contain antibiotics, since WWTP cannot eliminate the presence of antibiotics. Therefore, adsorption can be a sustainable option, compared to other tertiary treatments. In this direction, a versatile synthesis of poly(styrene-block-acrylic acid) diblock copolymer/Fe3O4 magnetic nanocomposite (abbreviated as P(St-b-AAc)/Fe3O4)) was achieved for environmental applications, and particularly for the removal of antibiotic compounds. For this reason, the synthesis of the P(St-b-AAc) diblock copolymer was conducted with a reversible addition fragmentation transfer (RAFT) method. Monodisperse superparamagnetic nanocomposite with carboxylic acid groups of acrylic acid was adsorbed on the surface of Fe3O4 nanoparticles. The nanocomposites were characterized with scanning electron microscopy (SEM), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM) analysis. Then, the nanoparticles were applied to remove ciprofloxacin (antibiotic drug compound) from aqueous solutions. The effects of various parameters, such as initial drug concentration, solution pH, adsorbent dosage, and contact time on the process were extensively studied. Operational parameters and their efficacy in the removal of Ciprofloxacin were studied. Kinetic and adsorption isothermal studies were also carried out. The maximum removal efficiency of ciprofloxacin (97.5%) was found at an initial concentration of 5 mg/L, pH 7, adsorbent's dosage 2 mg/L, contact time equal to 37.5 min. The initial concentration of antibiotic and the dose of the adsorbent presented the highest impact on efficiency. The adsorption of ciprofloxacin was better fitted to Langmuir isotherm (R2 = 0.9995), while the kinetics were better fitted to second-order kinetic equation (R2 = 0.9973).The proliferation of mobile devices such as smartphones and tablets with embedded sensors and communication features has led to the introduction of a novel sensing paradigm called mobile crowd sensing. Despite its opportunities and advantages over traditional wireless sensor networks, mobile crowd sensing still faces security and privacy issues, among other challenges. Specifically, the security and privacy of sensitive location information of users remain lingering issues, considering the "on" and "off" state of global positioning system sensor in smartphones. To address this problem, this paper proposes "SenseCrypt", a framework that automatically annotates and signcrypts sensitive location information of mobile crowd sensing users. The framework relies on K-means algorithm and a certificateless aggregate signcryption scheme (CLASC). It incorporates spatial coding as the data compression technique and message query telemetry transport as the messaging protocol. Results presented in this paper show that the proposed framework incurs low computational cost and communication overhead. Also, the framework is robust against privileged insider attack, replay and forgery attacks. Confidentiality, integrity and non-repudiation are security services offered by the proposed framework.Polyurethane foams are one of the most common auxetic structures regarding energy absorption enhancement. https://www.selleckchem.com/products/azd7648.html This present study evaluates the result reliability of two different numerical approaches, the H-method and the P-method, to obtain the best convergence solution. A polymeric re-entrant cell is created with a beam element and the results of the two different methods are compared. Additionally, the numerical results compare well with the analytical solution. The results show that there is a good agreement between converged FE models and the analytical solution. Regarding the computational cost, the P-method is more efficient for simulating the re-entrant structure subjected to axial loading. During the second part of this study, the re-entrant cell is used for generating a polymeric auxetic cellular tube. The mesh convergence study is performed on the cellular structures using the H- and P- methods. The cellular tube is subjected to tensional and compressive loading, the module of elasticity and Poisson's ration to calculate different aspect ratios. A nonlinear analysis is performed to compare the dynamic response of a cellular tube versus a solid tube. The crashworthiness indicators are addressed and the results are compared with equivalent solid tubes. The results show that the auxetic cellular tubes have better responses against compressive loading. The primary outcome of this research is to assess a reliable FE approach for re-entrant structures under axial loading.