Disparities in eating disorder (ED) risk, diagnosis, and treatment for those who occupy multiple marginalized social identities (e.g., combined racial/ethnic and sexual minority statuses), underscore the need for advancing multicultural research in the ED field. In this article, we argue that intersectionality-informed approaches, which examine the ways in which one's multiple social identities interact to inform risk for ED outcomes, offer an established framework for identifying frequently underserved individuals who may be at greatest risk for EDs. We highlight preliminary intersectional research in EDs and offer suggestions for further progression. In particular, we encourage future intersectionality-informed research to incorporate a broader range of social identities (e.g., age, ability status), consider the ways in which these identities may be dimensional and fluid, and embrace strengths-based approaches to illuminate dimensions of identity that may serve as protective factors. To support such research, we describe quantitative and qualitative methods for pursuing questions of intersectionality in ED investigations. Given the success of intersectionality-informed research in other areas of psychopathology and its relevance to ED as suggested by initial research, the continued pursuit of these approaches in EDs has high potential to improve identification and treatment for patients who have too often been overlooked.Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but may involve genetic, local mechanical, and systemic factors. Here, we will summarize the main systemic factors that shape cutaneous pathological scarring, especially keloid formation and aggravation. They include circulating cytokines, chemokines, growth factors, particular cell types, sex hormones, the systemic renin-angiotensin system, and vitamin D, all of which directly shape the angiogenesis, inflammation, fibrosis, and remodeling in pathological scars. There are also several environmental factors that more indirectly influence pathological scar formation or progression, namely diet, smoking, psychological stress, and exercise. Notably, **** of the evidence on these systemic factors focus on their effects on one pathological scar characteristic, namely their fibrosis. However, systemic factors probably also shape other pathological scar characteristics. We describe two new avenues of keloid research that may greatly improve our understanding of pathological scarring and the systemic factors that affect it. One is the multiple similarities between keloids and tumors; the other is the different stem-cell populations in keloids. We expect this research will greatly aid the development of diagnostic biomarkers for cutaneous pathological scars and drugs/techniques/regimens that prevent, improve, or cure these scars.Realization of reduced ionic (cationic and anionic) defects at the surface and grain boundaries (GBs) of perovskite films is vital to boost the power conversion efficiency of organic-inorganic halide perovskite (OIHP) solar cells. Although numerous strategies have been developed, effective passivation still remains a great challenge due to the complexity and diversity of these defects. Herein, a solid-state interdiffusion process using multi-cation hybrid halide perovskite quantum dots (QDs) is introduced as a strategy to heal the ionic defects at the surface and GBs. It is found that the solid-state interdiffusion process leads to a reduction in OIHP shallow defects. In addition, Cs+ distribution in QDs greatly influences the effectiveness of ionic defect passivation with significant enhancement to all photovoltaic performance characteristics observed on treating the solar cells with Cs0.05 (MA0.17 FA0.83 )0.95 PbBr3 (abbreviated as QDs-Cs5). This enables power conversion efficiency (PCE) exceeding 21% to be achieved with more than 90% of its initial PCE retained on exposure to continuous illumination of more than 550 h.Evidence suggests that vitamin D supplementation could potentially be effective either in treatment or prevention of coronavirus disease 2019 (Covid-19). https://www.selleckchem.com/ Indeed, several studies and trials have begun to investigate the impact of vitamin D supplementation on patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the potential mechanisms of vitamin D in the pathogenesis of Covid-19. We consider whether deficiency of vitamin D may be one of the underlying biological factors that could explain the excess mortality seen among non-Caucasians. We also raise several important questions which need to be addressed to provide a clear picture of the extent to which vitamin D supplementation may benefit patients with Covid-19, particularly those with underlying risk factors.Left ventricular pseudoaneurysm formation is a rare complication of transapical approach transcatheter aortic valve replacement. It can cause chest pain and shortness of breath or remain asymptomatic. Mortality rate is high, and therefore, timely diagnosis and management are essential. Different imaging modalities can provide anatomic or functional information and are essential for the primary diagnosis or during follow-up.A 3D hierarchical carbon cloth/nitrogen-doped carbon nanowires/Ni@MnO2 (CC/N-CNWs/Ni@MnO2 ) nanocomposite electrode was rationally designed and prepared by electrodeposition. The N-CNWs derived from polypyrrole (PPy) nanowires on the carbon cloth have an open framework structure, which greatly increases the contact area between the electrode and electrolyte and provides short diffusion paths. The incorporation of the Ni layer between the N-CNWs and MnO2 is beneficial for significantly enhancing the electrical conductivity and boosting fast charge transfer as well as improving the charge-collection capacity. Thus, the as-prepared 3D hierarchical CC/N-CNWs/Ni@MnO2 electrode exhibits a higher specific capacitance of 571.4 F g-1 compared with those of CC/N-CNWs@MnO2 (311 F g-1 ), CC/Ni@MnO2 (196.6 F g-1 ), and CC@MnO2 (186.1 F g-1 ) at 1 A g-1 and remarkable rate capability (367.5 F g-1 at 10 A g-1 ). Moreover, asymmetric supercapacitors constructed with CC/N-CNWs/Ni@MnO2 as cathode material and activated carbon as anode material deliver an impressive energy density of 36.
Disparities in eating disorder (ED) risk, diagnosis, and treatment for those who occupy multiple marginalized social identities (e.g., combined racial/ethnic and sexual minority statuses), underscore the need for advancing multicultural research in the ED field. In this article, we argue that intersectionality-informed approaches, which examine the ways in which one's multiple social identities interact to inform risk for ED outcomes, offer an established framework for identifying frequently underserved individuals who may be at greatest risk for EDs. We highlight preliminary intersectional research in EDs and offer suggestions for further progression. In particular, we encourage future intersectionality-informed research to incorporate a broader range of social identities (e.g., age, ability status), consider the ways in which these identities may be dimensional and fluid, and embrace strengths-based approaches to illuminate dimensions of identity that may serve as protective factors. To support such research, we describe quantitative and qualitative methods for pursuing questions of intersectionality in ED investigations. Given the success of intersectionality-informed research in other areas of psychopathology and its relevance to ED as suggested by initial research, the continued pursuit of these approaches in EDs has high potential to improve identification and treatment for patients who have too often been overlooked.Cutaneous pathological scars are fibrotic lesions that grow continuously, invade the adjacent skin, and are erythematous, itchy, and painful. Their etiology remains unclear but may involve genetic, local mechanical, and systemic factors. Here, we will summarize the main systemic factors that shape cutaneous pathological scarring, especially keloid formation and aggravation. They include circulating cytokines, chemokines, growth factors, particular cell types, sex hormones, the systemic renin-angiotensin system, and vitamin D, all of which directly shape the angiogenesis, inflammation, fibrosis, and remodeling in pathological scars. There are also several environmental factors that more indirectly influence pathological scar formation or progression, namely diet, smoking, psychological stress, and exercise. Notably, much of the evidence on these systemic factors focus on their effects on one pathological scar characteristic, namely their fibrosis. However, systemic factors probably also shape other pathological scar characteristics. We describe two new avenues of keloid research that may greatly improve our understanding of pathological scarring and the systemic factors that affect it. One is the multiple similarities between keloids and tumors; the other is the different stem-cell populations in keloids. We expect this research will greatly aid the development of diagnostic biomarkers for cutaneous pathological scars and drugs/techniques/regimens that prevent, improve, or cure these scars.Realization of reduced ionic (cationic and anionic) defects at the surface and grain boundaries (GBs) of perovskite films is vital to boost the power conversion efficiency of organic-inorganic halide perovskite (OIHP) solar cells. Although numerous strategies have been developed, effective passivation still remains a great challenge due to the complexity and diversity of these defects. Herein, a solid-state interdiffusion process using multi-cation hybrid halide perovskite quantum dots (QDs) is introduced as a strategy to heal the ionic defects at the surface and GBs. It is found that the solid-state interdiffusion process leads to a reduction in OIHP shallow defects. In addition, Cs+ distribution in QDs greatly influences the effectiveness of ionic defect passivation with significant enhancement to all photovoltaic performance characteristics observed on treating the solar cells with Cs0.05 (MA0.17 FA0.83 )0.95 PbBr3 (abbreviated as QDs-Cs5). This enables power conversion efficiency (PCE) exceeding 21% to be achieved with more than 90% of its initial PCE retained on exposure to continuous illumination of more than 550 h.Evidence suggests that vitamin D supplementation could potentially be effective either in treatment or prevention of coronavirus disease 2019 (Covid-19). https://www.selleckchem.com/ Indeed, several studies and trials have begun to investigate the impact of vitamin D supplementation on patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we focus on the potential mechanisms of vitamin D in the pathogenesis of Covid-19. We consider whether deficiency of vitamin D may be one of the underlying biological factors that could explain the excess mortality seen among non-Caucasians. We also raise several important questions which need to be addressed to provide a clear picture of the extent to which vitamin D supplementation may benefit patients with Covid-19, particularly those with underlying risk factors.Left ventricular pseudoaneurysm formation is a rare complication of transapical approach transcatheter aortic valve replacement. It can cause chest pain and shortness of breath or remain asymptomatic. Mortality rate is high, and therefore, timely diagnosis and management are essential. Different imaging modalities can provide anatomic or functional information and are essential for the primary diagnosis or during follow-up.A 3D hierarchical carbon cloth/nitrogen-doped carbon nanowires/Ni@MnO2 (CC/N-CNWs/Ni@MnO2 ) nanocomposite electrode was rationally designed and prepared by electrodeposition. The N-CNWs derived from polypyrrole (PPy) nanowires on the carbon cloth have an open framework structure, which greatly increases the contact area between the electrode and electrolyte and provides short diffusion paths. The incorporation of the Ni layer between the N-CNWs and MnO2 is beneficial for significantly enhancing the electrical conductivity and boosting fast charge transfer as well as improving the charge-collection capacity. Thus, the as-prepared 3D hierarchical CC/N-CNWs/Ni@MnO2 electrode exhibits a higher specific capacitance of 571.4 F g-1 compared with those of CC/N-CNWs@MnO2 (311 F g-1 ), CC/Ni@MnO2 (196.6 F g-1 ), and CC@MnO2 (186.1 F g-1 ) at 1 A g-1 and remarkable rate capability (367.5 F g-1 at 10 A g-1 ). Moreover, asymmetric supercapacitors constructed with CC/N-CNWs/Ni@MnO2 as cathode material and activated carbon as anode material deliver an impressive energy density of 36.
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