04, 95% confidence interval [CI] 1.28-2.26, p = 0.003; HR 1.81, 95% CI 1.11-2.96, p = 0.018). TBS unadjusted and FRAX-MOF-BMD adjusted also predicted clinical spine fracture (N = 7) (HR 2.50, 95% CI 1.17-5.37; p = 0.019; HR 2.40 95% CI 1.1-5.25; p = 0.028). Higher HRs were observed for prediction of hip fracture (N = 6), but these did not achieve statistical significance (FRAX-adjusted HR 1.74, 95% 0.73-4.17; p = 0.211). https://www.selleckchem.com/ Unadjusted models show TBS was predictive of all fracture (N = 27) (HR 1.60, 95% CI 1.08-2.39; p = 0.020), which was borderline significant after adjustment for FRAX-MOF-BMD (HR 1.51, 95% CI 1.00-2.29; p = 0.052). CONCLUSION We report the first analysis of TBS for fracture prediction as an incident event in AS. TBS independently predicted major osteoporotic and clinical spine fracture in AS independent of FRAX. RATIONALE AND OBJECTIVES To evaluate the quality and value of contrast-enhanced (CE) chest- and abdominal computed tomography (CT) and CT angiography in neonates, children, and adults undergoing extracorporeal membrane oxygenation (ECMO) using a customized protocol for contrast delivery. MATERIALS AND METHODS All patients admitted for CE thoracic- and/or abdominal CT while on ECMO were prospectively included in the study. A protocol for contrast delivery adapted for the type of ECMO circulation, cannulation sites, anatomy of interest, and desired contrast phase was applied. Clinical information, ECMO and CT technique, including contrast administration strategy, was noted for each patient. Two radiologists separately evaluated the quality of the scan. The value of the examination was decided in consensus with the referring ECMO physician. RESULTS One hundred thirty CE thoracoabdominal scans were performed at 103 different occasions during the study time. Eighty-nine scans were performed during veno-arterial ECMO and 41 during veno-venous ECMO. In the majority, contrast was delivered to the oxygenator with preserved ECMO flow. A peripheral or central venous line with reduced flow was utilized in the remaining cases. Mean scan quality was graded 4.2 on a five-grade scale. In 56% of the examinations, the findings affected the immediate treatment of the patient. CONCLUSION High-quality CT and CT angiography can be achieved in ECMO patients of different ages and clinical issues considering the type of ECMO circulation, ECMO cannulation sites, preferred contrast phase and anatomy of interest. CT diagnoses affect the treatment of the patient. RATIONALE AND OBJECTIVES The purpose of this study was to investigate the potential effects of patient size and radiation dose on the accuracy of iodine quantification using dual-source dual-energy computed tomography (CT). MATERIALS AND METHODS Three phantoms representing different patient sizes were constructed, containing iodine inserts with concentrations from 0 to 20 mg/ml. Dual-energy CT scans were performed at six dose levels from 2 to 30 mGy. Iodine concentrations were measured using a three-material-decomposition algorithm and their accuracy was assessed. RESULTS In a small phantom, iodine quantification was accurate and consistent at all dose levels. In a medium phantom, minor underestimations were observed, and the results were consistent except at low dose. In the large phantom, more significant underestimation of iodine concentration was observed at higher doses (≥15 mGy), which was attributed to the beam-hardening effect. At lower doses, increasing upward bias was observed in the CT number, leading to significant overestimations of both iodine concentration and fat fraction, which was attributed to the photon-starvation effect. The severity of the latter effect was determined by mA instead of mAs, suggesting that the electronic noise, rather than the quantum noise, was responsible for the bias. Using higher kVp for the low-energy tube was found to alleviate these effects. CONCLUSION Reliable iodine quantification can be achieved using dual-source CT, but the result can be affected by patient size and dose rate. In large patients, biases may occur due to the beam-hardening and the photon-starvation effects, in which case higher dose rate and higher kVp are recommended to minimize these effects. OBJECTIVE The purpose of this study was to determine if submental intubation during maxillomandibular advancement (MMA) reduces the development of nasal obstruction in patients with obstructive sleep apnea (OSA). STUDY DESIGN This study was a prospective, single cohort of consecutive adult patients undergoing MMA surgery for OSA at a single institution. The primary outcome measure was the development of nasal obstruction using the Nasal Obstruction Symptom Evaluation scale. Secondary outcomes included the rate of reintubation, submandibular duct function, development of neck infection, the need for subsequent surgical correction of nasal obstruction, and changes in the Apnea-Hypopnea Index. RESULTS Twenty consecutive patients (85% male, mean age 47 years) were included in the study. Nasal Obstruction Symptom Evaluation scores improved in 88% of patients, with a mean improvement from 46.6 ± 28.9 to 15.9 ± 20.9 at 3 months (P less then .01). No participant required reintubation, and all patients had adequate bilateral submandibular gland function at follow-up. The mean Apnea-Hypopnea Index improved from 58.1 ± 32.0 to 8.3 ± 4.7 (P less then .01). CONCLUSION Submental intubation for patients undergoing MMA for OSA appears to be a well-tolerated, expeditious alternative to nasal intubation with excellent nasal breathing results. Larger, prospective investigations to confirm these findings should be considered. OBJECTIVES The aim of this study was to assess diagnosis and treatment of submandibular duct stenosis caused by dental prostheses. STUDY DESIGN This retrospective study included 9 patients with papillary stenosis caused by physical irritation of the Wharton duct ostium by a mandibular dental prosthesis. Diagnostics included physical examination, as well as transcutaneous and transoral ultrasound examinations. Treatment consisted of duct incision, papillotomy, and subsequent sialendoscopy. After surgery, patients were advised to have the dental prosthesis altered by the dentist and to have regular gland massage. Follow-up data were obtained via telephone interviews. The most important outcome parameter was a symptom-free state. RESULTS In all 9 patients, the insertion of the sialendoscope was initially impossible because of the stenosis. After duct incision, sialendoscopy ruled out other obstructive causes and inflammatory states, leaving the dental prosthesis as the only underlying cause of the obstruction. Seven of the 9 treated patients were interviewed after a follow-up period of 28.