In this study, we present a mathematical model of dengue fever transmission with hospitalization to describe the dynamics of the infection. We estimated the basic reproduction number for the infected cases in East Java Province for the year 2018 is R 0 ≈ 1.1138 . The parameters of the dengue model are estimated by using the confirmed notified cases of East Java province, Indonesia for the year 2018. We formulated the model for dengue with hospitalization and present its dynamics in details. Initially, we present the basic mathematical results and then show briefly the stability results for the model. Further, we formulate an optimal control problem with control functions and obtain the optimal control characterization. The optimal control problem is solved numerically and the results comprised of controls system for different strategies. The controls such as prevention and insecticide could use the best role in the disease eradication from the community. Our results suggest that the prevention of humans from the mosquitoes and the insecticide spray on mosquitoes can significantly reduce the infection of dengue fever and may reduce further spread of infection in the community.Synthesis of 1,3- dioxane and 1,3-dioxolane, using sulfated CeO2-ZrO2 catalyst for acetalization of glycerol with benzaldehyde, is the focus of present work. SO42-/CeO2-ZrO2 catalyst was synthesized using combustion method. Experiments were carried out to analyze the effect of various solvents (n-hexane, toluene, tert-butyl alcohol, pentanol), molar ratios (13, 15, 17), catalyst loadings (3 wt%, 5 wt%, 9 wt %) and temperatures (80 °C, 90 °C, 100 °C) on glycerol conversion and selectivity of the products. Selectivity of 87.20% dioxolane and 12.80% dioxane was obtained at molar ratio of 13, 9 wt% catalyst loading and temperature of 100 °C.Strong NH3 desorption peak from NH3-TPD study indicated the high acidic strength of sulphated catalyst. Strong surface acidity and surface porosity (observed from TEM and SEM analysis) contributed to an enhanced activity of the catalyst for glycerol acetalization reaction. The kinetics of the reaction was studied using an elementary kinetic law. A correlation coefficient of 0.98 from the selected kinetic model proved that the rate of acetalization reaction was dependent on glycerol concentration and acetal formation was instantaneous. The study demonstrated the application of an environmentally benign, inexpensive, thermally stable, active SO42-/CeO2-ZrO2 catalyst for glycerol acetalization reaction to synthesize 1,3-dioxolane as the desired product.Alpha-ACTN4, a member of alpha-actinin family is critical for cell motility through its regulated binding of actin filaments. We previously found that EGF exposure of cells triggers the tyrosyl-phosphorylation of ACTN4 in fibroblasts that dramatically downregulates its binding to actin filaments. However, the exact kinase remained uncertain. In the present study, we report that the phosphorylation of ACTN4 occurs within seconds upon EGF treatments and is accomplished via direct interaction of ACTN4 with the EGF receptor. The major binding domain of ACTN4 for EGF receptor is mapped to the N-terminal 32 amino acids. A second domain minimizes the interaction, as truncation of the C-terminal tail enhances ACTN4 binding to EGF receptor. A mimetic phosphorylated ACTN4, Y4/31E, presents low binding to EGF receptor. Overexpression of EGF receptor in melanoma cell lines, also accomplishes the phosphorylation of ACTN4 in the presence of EGF. These findings suggest that the binding of ACTN4 to EGFR enables its direct and rapid phosphorylation resulting in dissociation from EGFR and decreased binding to actin filaments.The focal and progressive degeneration of dopaminergic (DA) neurons in ventral midbrain has made Parkinson's disease (PD) a particularly interesting target of cell-based therapies. However, ethical issues and limited tissue availability have so far hindered the widespread use of human fetal tissue in cell-replacement therapy. DA neurons derived from human pluripotent stem cells (hPSCs) offer unprecedented opportunities to access a renewable source of cells suitable for PD therapeutic applications. To better understand the development and functional properties of stem-cell derived DA neurons, we generated targeted hPSC lines with the gene coding for Cre recombinase knocked into the TH locus. When combined with flexed GFP, they serve as reporter cell lines able to identify and isolate TH+ neurons in vitro and after transplantation in vivo. These TH-Cre lines provide a valuable genetic tool to manipulate DA neurons useful for the design of more precise DA differentiation protocols and the study of these cells after transplantation in pre-clinical animal models of PD.The HIV Vaccine Trials Network (HVTN) is the world's largest publicly funded, multi-disciplinary international collaboration facilitating the development of vaccines to prevent HIV/AIDS and has conducted the vast majority of HIV/AIDS clinical trials since its inception in 1999. Although scientific findings from the program have been published in scholarly journals, the impact of a large scientific research network such as the HVTN on the HIV/AIDS vaccine field has not been assessed. This paper describes and elucidates the productivity, influence, and collaboration among HVTN researchers over the last two decades. Our analyses indicate that the HVTN has funded a large number of HIV/AIDS vaccine safety and efficacy clinical trials through a strong global network of clinical sites. In addition, several metrics indicate HVTN researchers also published original research articles that are influential in the HIV vaccine field. Scientific research collaboration is critically important in a complex and multidisciplinary field such as HIV vaccine development as it allows improved sharing of knowledge and expertise as well as the pooling of resources and data. https://www.selleckchem.com/products/phycocyanobilin.html We found that collaboration in the HIV vaccine field increased during this time period and collaboration among HVTN authors increased even more. Combining these productivity, influence, and collaboration metrics with research outcomes can provide a comprehensive assessment of large complex programs such as the HVTN.