Training load (TL) is a modifiable risk factor that may provide practitioners with opportunities to mitigate injury risk and increase sports performance. A regular problem encountered by practitioners, however, is the issue of missing TL data. The purpose of this study was to examine the impact of missing TL data in team sports and to offer a practical and effective method of missing value imputation (MVI) to address this. Session rating of perceived exertion (sRPE) data from 10 male professional soccer players (age, 24.8 ± 5.0 years; height, 181.2 ± 5.1 cm; mass, 78.7 ± 6.4 kg) were collected over a 32-week season. Data were randomly removed at a range of 5-50% in increments of 5% and data were imputed using 12 MVI methods. Performance was measured using the normalized root-mean-square error and mean of absolute deviations. The best-fitting MVI method across all levels of missingness was Daily Team Mean (DTMean). Not addressing missing sRPE data may lead to more inaccurate calculations of other TL metrics (e.g., acute chronic workload ratio, training monotony, training strain). The DTMean MVI method may provide practitioners with a practical and effective approach to addressing the negative consequences of missing TL data.Clinical relevance Accurate measurement of several physiognomy parameters (interpupillary, nasopupillary and fitting height distances) and frame angles (pantoscopic and frame wrap angles) is essential for prescribing progressive addition lenses for presbyopic patients.Background Few reports have described the repeatability of different devices commonly used to conduct essential measurements for prescribing progressive addition lenses.Methods Interpupillary, nasopupillary (at far and near distances) and fitting point heights were measured three consecutive times in 21 healthy volunteers with four devices (traditional frame ruler, PD-5 interpupilometer, OptiCenter, and VisiOffice). Pantoscopic and wrap frame angles were also measured three times with Essilor standard pantoscopic ruler, Opticenter and VisiOffice.Results The frame ruler, PD-5 and Opticenter showed better repeatability for interpupillary and nasopupillary distance (co-efficient of variation close to 1%, within-subject standard deviation or Sw 2.50º), but acceptable repeatability with Opticenter (co-efficient of variation less then 1%, Sw = 0.05º).Conclusions Interpupillary and nasopupillary distance measurement showed acceptable repeatability with all the assessed methods; however, these measurements alone are no longer sufficient for free-form progressive addition lens prescription, which requires fitting point heights and pantoscopic and frame wrap angle measurement. Such measures display a lack of repeatability that could induce centration errors and could affect vision and/or adaptation of the user.Research studies exploring the association of cognitive complaints with objectively assessed cognitive decline report inconsistent results. However, many of these have methodological limitations. We investigated whether 1) more severe subjective cognitive decline (SCD) and subjective memory decline (SMD) predict change in objectively assessed global cognition, remote memory, recent memory, learning; 2) the predictive value of more severe SMD over change in objectively assessed remote memory, recent memory, and learning is stronger for individuals that report an SMD that started within the past five years than for those that report an SMD that started five or more years previously and/or stronger for those that experienced SMD within the past two years than for those who had not; and 3) greater depression and anxiety are associated with more severe SCD and SMD. We used two-year longitudinal data from the CFAS-Wales study (N = 1,531; mean (SD) age = 73.0 (6.0) years). We fitted linear regression models. More severe SCD and SMD did not predict change in objectively assessed global cognition, remote memory, and recent memory but predicted lower scores in learning. The prediction of SMD over change in learning was not stronger when individuals reported an SMD that started within the past five years compared to when they reported an SMD that started five or more years previously nor when individuals reported an SMD that started within the past two years than those who did not. Greater depression and anxiety were associated with more severe SCD and SMD. More severe SMD may be useful for predicting lower learning ability and for identifying individuals experiencing depression and anxiety.Exposure to fake news stories can result in false memories for the events portrayed, and this effect can be enhanced if the stories conform to the reader's ideological position. We exposed 1299 UK residents to fabricated news stories about Brexit. 44% of participants reported a false memory for at least one fabricated story, with a higher rate of false memories for stories that reflected poorly on the opposing side. This effect of ideological congruency was somewhat greater among participants who were exposed to a threat to their social identity as a Leave or Remain supporter; however, this moderating effect was only statistically significant in exploratory analyses using a more conservative definition of false memory. Participants with higher cognitive ability and analytical reasoning scores were less susceptible to false memories. Individuals with better knowledge about Brexit showed better discrimination between true and false stories, while self-reported engagement with the Brexit debate was associated with an increased tendency to "remember" any story, regardless of its truth. These results implicate a combination of social and individual factors in the development of false memories from fake news, and suggest that exposure to social identity threats may enhance the polarising effects of fake news.Objectives To investigate the clinical efficacy and safety of ceftobiprole for acute bacterial skin and skin structure infections (ABSSSIs).Methods PubMed, Web of Science, EBSO, Ovid Medline, ClinicalTrial.gov and Cochrane Library were searched until 25 December 2020. Only randomized controlled trials that compared the treatment efficacy of ceftobiprole with that of other antibiotics for adult patients with ABSSSIs were included in this meta-analysis.Results The 3 RCTs involving 2291 adult patients with ABSSSIs were included. https://www.selleckchem.com/TGF-beta.html No significant difference in clinical success, as measured by the TOC, was observed between ceftobiprole and comparators among the intention-to-treat population (OR, 1.06; 95% CI, 0.85-1.33; I2 = 0%) and clinical evaluable population (OR, 1.17; 95% CI, 0.76-1.79; I2 = 17%). Ceftobiprole was associated with a similar risk of adverse events (AEs) to that of comparators.Conclusions Ceftobiprole can achieve similar clinical and microbiological responses as alternative antibiotics in patients with ABSSSIs.