© 2020 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.OBJECTIVE Women with breast cancer are exposed to various stressors, and self-care behaviors play an important role in their recovery. However, very few studies have investigated self-care behaviors specifically for women with breast cancer. The current study examined the relationship between perceived stress and self-care behaviors, and explored whether self-compassion moderated this relationship. METHODS A sample of 210 women with breast cancer aged 27 to 60 years old from three hospitals in Tehran, Iran completed online self-report questionnaires of self-care behaviors, self-compassion, and perceived stress. RESULTS Data analyses with structural equation modeling showed that perceived stress (β = -.37, P  less then  .01) and self-compassion (β = .38, P  less then  .01) were significant predictors of self-care behaviors. The interaction-moderation analysis showed that self-compassion acted as a moderator between perceived stress and self-care behaviors. CONCLUSIONS The findings enhance our understanding about the protective role of self-compassion in the relationship between perceived stress and self-care behaviors in women with breast cancer. © 2020 John Wiley & Sons, Ltd.PURPOSE Exaggerated exercise blood pressure (BP) is associated with altered cardiac structure and increased cardiovascular risk. Fitness modifies these associations, but the effect in healthy adolescents is unknown. We performed an observational study to determine the influence of fitness on post-exercise BP, and on its relationship with cardiac structure in adolescents. METHODS 4835 adolescents from the Avon Longitudinal Study of Parents and Children, (15.4(0.3) years, 49% male) completed a submaximal cycle test. Fitness was estimated as physical work capacity 170 adjusted for lean body-mass and post-exercise BP measured immediately post-test. Cardiovascular structure and function, including left-ventricular (LV) mass (n=1589), left atrium (LA) size (n=1466), cardiac output (CO, n=1610) and total peripheral resistance (TPR, n=1610) were measured at rest by echocardiography 2.4(0.4) years later. RESULTS Post-exercise systolic BP increased step-wise by fitness tertile (131.2mmHg [130.4,132.1]; 137.3mmHg [136.5,138.0]; 142.3mmHg [141.5,143.1]). Each 5mmHg of post-exercise systolic BP was associated with 2.46g [1.91,3.01] greater LV mass, 0.02cm [0.02,0.03] greater LA size and 0.25g/m2.7 [0.14,0.36] greater LV mass index. Adjustment for fitness abolished associations (0.29g [-0.16,0.74]; 0.01cm [-0.001,0.014] and 0.08g/m2.7 [-0.001,0.002]). Similar associations between post-exercise systolic BP and each outcome were found between the lowest and highest fitness thirds. CO increased with fitness third (difference 0.06L/min [-0.05,0.17]; 0.23L/min [0.12,0.34]) while TPR decreased (difference -0.13mmHg·min/L [-0.84,0.59]; -1.08mmHg·min/L [-0.1.80,0.35]). CONCLUSIONS Post-exercise systolic BP increased with fitness, which modified its association with cardiac structure. Higher CO, but lower TPR suggests a physiologically adapted cardiovascular system with greater fitness, highlighting the importance of fitness in adolescence. This article is protected by copyright. All rights reserved.An efficient method for the enzymatic synthesis of cephalexin (CEX) from 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) and d-phenylglycine methyl ester (PGME) using immobilized penicillin G acylase (IPGA) as catalyst in a suspension aqueous solution system was developed, where the reactant 7-ADCA and product CEX are mainly present as solid particles. The effects of key factors on the enzymatic synthesis were investigated. Results showed that continuous feeding of PGME was more efficient for the synthesis of CEX than the batch mode. Under the optimized conditions, the maximum 7-ADCA conversion ratio of 99.3% and productivity of 200 mmol/L/H were achieved, both of which are much superior to the homogeneous aqueous solution system. Besides, IPGA still retained 95.4% of its initial activity after 10 cycles of enzymatic synthesis, indicating the excellent stability of this approach. The developed approach shows great potential for the industrial production of CEX via an enzyme-based route. © 2020 International Union of Biochemistry and Molecular Biology, Inc.OBJECTIVES Sport-related concussions are an increasingly recognized health problem. Soccer is the most popular sport in the world although recent studies on concussion incidence are scarce. Here, a nationwide prospective study on concussion incidence, symptom severity, risk factors, gender differences, and return-to-play after concussion was performed in 51 Swedish elite soccer teams during the 2017 season. METHODS In the 1st and 2nd soccer leagues for men and women, a Sport Concussion Assessment Tool (SCAT)-based questionnaire study was performed at preseason (baseline) and from 48 hours to 3 months post-concussion. RESULTS We followed 959 players (389 women, 570 men) for 25 146 player game hours (9867 hours for women, 15 279 hours for men). Concussion incidence (n = 36 concussions during the season) was 1.19/1000 player game hours (females 1.22/1000 hours, males 1.18/1000 hours; P = .85). Twenty-seven percent of all players (8% of females, 40% of males) continued to play immediately after the concussion. When compared to male players, female players had worse initial symptom severity scores (median and IQR 30 (17-50.5) vs 11 (4-26.25), P = .02) on SCAT and longer return-to-play (P = .02). Risk factors for concussion were baseline symptoms and previous concussion. CONCLUSION In Swedish elite soccer, the concussion incidence was 1.19/1000 without gender differences. Most players recovered to play within 4 weeks post-injury. https://www.selleckchem.com/CDK.html Almost one third of players continued to play at time of concussion. Female players had worse initial symptoms and longer return-to-play time than males, and a prolonged recovery beyond 3 months was only observed among female players. © 2020 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.