To solve the nonlinear equation and the TVLP, a novel continuous-time ZNN (CTZNN) is designed and its corresponding discrete-time ZNN (DTZNN) is established using an extrapolated backward differentiation formula. Theoretical analysis is rigorously conducted to prove the convergence of the neural approach. Numerical studies are performed by comparing the DTZNN solver and the state-of-the-art (SOTA) linear programming (LP) solvers. Comparative results show that the DTZNN consumes the least computing time and can be a powerful alternative to the SOTA solvers. The DTZNN and the INVM scheme are finally applied to control two kinematically redundant robots. Both simulative and experimental results show that the robots successfully accomplish user-specified path-tracking tasks, verifying the effectiveness and practicability of the proposed neural approach and the INVM scheme equipped with the new joint-limit handling technique.The goal of multi-view clustering is to partition samples into different subsets according to their diverse features. Previous multi-view clustering methods mainly exist two forms multi-view spectral clustering and multi-view matrix factorization. Although they have shown excellent performance in many occasions, there are still many disadvantages. For example, multi-view spectral clustering usually needs to perform postprocessing. Multi-view matrix factorization directly decomposes the original data features. When the size of features is large, it encounters the expensive time consumption to decompose these data features thoroughly. Therefore, we proposed a novel multi-view clustering approach. The main advantages include the following three aspects 1) it searches for a common joint graph across multiple views, which fully explores the hidden structure information by utilizing the compatibility among views; 2) the introduced nonnegative constraint manipulates that the final clustering results can be directly obtained; and 3) straightforwardly decomposing the similarity matrix can transform the eigenvalue factorization in spectral clustering with computational complexity O(n³) into the singular value decomposition (SVD) with O(nc²) time cost, where n and c, respectively, denote the numbers of samples and classes. Thus, the computational efficiency can be improved. Moreover, in order to learn a better clustering model, we set that the constructed similarity graph approximates each view affinity graph as close as possible by adding the constraint as the initial affinity matrices own. Furthermore, substantial experiments are conducted, which verifies the superiority of the proposed two clustering methods comparing with single-view clustering approaches and state-of-the-art multi-view clustering methods.Classification methods for streaming data are not new, but very few current frameworks address all three of the most common problems with these tasks concept drift, noise, and the exorbitant costs associated with labeling the unlabeled instances in data streams. Motivated by this gap in the field, we developed an active learning framework based on a dual-query strategy and Ebbinghaus's law of human memory cognition. Called CogDQS, the query strategy samples only the most representative instances for manual annotation based on local density and uncertainty, thus significantly reducing the cost of labeling. The policy for discerning drift from noise and replacing outdated instances with new concepts is based on the three criteria of the Ebbinghaus forgetting curve recall, the fading period, and the memory strength. Simulations comparing CogDQS with baselines on six different data streams containing gradual drift or abrupt drift with and without noise show that our approach produces accurate, stable models with good generalization ability at minimal labeling, storage, and computation costs.Clustering single-cell RNA sequence (scRNA-seq) data poses statistical and computational challenges due to their high-dimensionality and data-sparsity, also known as 'dropout' events. Recently, Regularized Auto-Encoder (RAE) based deep neural network models have achieved remarkable success in learning robust low-dimensional representations. The basic idea in RAEs is to learn a non-linear mapping from the high-dimensional data space to a low-dimensional latent space and vice-versa, simultaneously imposing a distributional prior on the latent space, which brings in a regularization effect. This paper argues that RAEs suffer from the infamous problem of bias-variance trade-off in their naive formulation. While a simple AE without a latent regularization results in data over-fitting, a very strong prior leads to under-representation and thus bad clustering. To address the above issues, we propose a modified RAE framework (called the scRAE) for effective clustering of the single-cell RNA sequencing data. scRAE consists of deterministic AE with a flexibly learnable prior generator network, which is jointly trained with the AE. This facilitates scRAE to trade-off better between the bias and variance in the latent space. We demonstrate the efficacy of the proposed method through extensive experimentation on several real-world single-cell Gene expression datasets.Sleep disorder diagnosis relies on the analysis of polysomnography (PSG) records. As a preliminary step of this examination, sleep stages are systematically determined. In practice, sleep stage classification relies on the visual inspection of 30-second epochs of polysomnography signals. Numerous automatic approaches have been developed to replace this tedious and expensive task. Although these methods demonstrated better performance than human sleep experts on specific datasets, they remain largely unused in sleep clinics. The main reason is that each sleep clinic uses a specific PSG montage that most automatic approaches cannot handle out-of-the-box. Moreover, even when the PSG montage is compatible, publications have shown that automatic approaches perform poorly on unseen data with different demographics. To address these issues, we introduce RobustSleepNet, a deep learning model for automatic sleep stage classification able to handle arbitrary PSG montages. https://www.selleckchem.com/products/pd0166285.html We trained and evaluated this model in a leave-one-out-dataset fashion on a large corpus of 8 heterogeneous sleep staging datasets to make it robust to demographic changes.
To solve the nonlinear equation and the TVLP, a novel continuous-time ZNN (CTZNN) is designed and its corresponding discrete-time ZNN (DTZNN) is established using an extrapolated backward differentiation formula. Theoretical analysis is rigorously conducted to prove the convergence of the neural approach. Numerical studies are performed by comparing the DTZNN solver and the state-of-the-art (SOTA) linear programming (LP) solvers. Comparative results show that the DTZNN consumes the least computing time and can be a powerful alternative to the SOTA solvers. The DTZNN and the INVM scheme are finally applied to control two kinematically redundant robots. Both simulative and experimental results show that the robots successfully accomplish user-specified path-tracking tasks, verifying the effectiveness and practicability of the proposed neural approach and the INVM scheme equipped with the new joint-limit handling technique.The goal of multi-view clustering is to partition samples into different subsets according to their diverse features. Previous multi-view clustering methods mainly exist two forms multi-view spectral clustering and multi-view matrix factorization. Although they have shown excellent performance in many occasions, there are still many disadvantages. For example, multi-view spectral clustering usually needs to perform postprocessing. Multi-view matrix factorization directly decomposes the original data features. When the size of features is large, it encounters the expensive time consumption to decompose these data features thoroughly. Therefore, we proposed a novel multi-view clustering approach. The main advantages include the following three aspects 1) it searches for a common joint graph across multiple views, which fully explores the hidden structure information by utilizing the compatibility among views; 2) the introduced nonnegative constraint manipulates that the final clustering results can be directly obtained; and 3) straightforwardly decomposing the similarity matrix can transform the eigenvalue factorization in spectral clustering with computational complexity O(n³) into the singular value decomposition (SVD) with O(nc²) time cost, where n and c, respectively, denote the numbers of samples and classes. Thus, the computational efficiency can be improved. Moreover, in order to learn a better clustering model, we set that the constructed similarity graph approximates each view affinity graph as close as possible by adding the constraint as the initial affinity matrices own. Furthermore, substantial experiments are conducted, which verifies the superiority of the proposed two clustering methods comparing with single-view clustering approaches and state-of-the-art multi-view clustering methods.Classification methods for streaming data are not new, but very few current frameworks address all three of the most common problems with these tasks concept drift, noise, and the exorbitant costs associated with labeling the unlabeled instances in data streams. Motivated by this gap in the field, we developed an active learning framework based on a dual-query strategy and Ebbinghaus's law of human memory cognition. Called CogDQS, the query strategy samples only the most representative instances for manual annotation based on local density and uncertainty, thus significantly reducing the cost of labeling. The policy for discerning drift from noise and replacing outdated instances with new concepts is based on the three criteria of the Ebbinghaus forgetting curve recall, the fading period, and the memory strength. Simulations comparing CogDQS with baselines on six different data streams containing gradual drift or abrupt drift with and without noise show that our approach produces accurate, stable models with good generalization ability at minimal labeling, storage, and computation costs.Clustering single-cell RNA sequence (scRNA-seq) data poses statistical and computational challenges due to their high-dimensionality and data-sparsity, also known as 'dropout' events. Recently, Regularized Auto-Encoder (RAE) based deep neural network models have achieved remarkable success in learning robust low-dimensional representations. The basic idea in RAEs is to learn a non-linear mapping from the high-dimensional data space to a low-dimensional latent space and vice-versa, simultaneously imposing a distributional prior on the latent space, which brings in a regularization effect. This paper argues that RAEs suffer from the infamous problem of bias-variance trade-off in their naive formulation. While a simple AE without a latent regularization results in data over-fitting, a very strong prior leads to under-representation and thus bad clustering. To address the above issues, we propose a modified RAE framework (called the scRAE) for effective clustering of the single-cell RNA sequencing data. scRAE consists of deterministic AE with a flexibly learnable prior generator network, which is jointly trained with the AE. This facilitates scRAE to trade-off better between the bias and variance in the latent space. We demonstrate the efficacy of the proposed method through extensive experimentation on several real-world single-cell Gene expression datasets.Sleep disorder diagnosis relies on the analysis of polysomnography (PSG) records. As a preliminary step of this examination, sleep stages are systematically determined. In practice, sleep stage classification relies on the visual inspection of 30-second epochs of polysomnography signals. Numerous automatic approaches have been developed to replace this tedious and expensive task. Although these methods demonstrated better performance than human sleep experts on specific datasets, they remain largely unused in sleep clinics. The main reason is that each sleep clinic uses a specific PSG montage that most automatic approaches cannot handle out-of-the-box. Moreover, even when the PSG montage is compatible, publications have shown that automatic approaches perform poorly on unseen data with different demographics. To address these issues, we introduce RobustSleepNet, a deep learning model for automatic sleep stage classification able to handle arbitrary PSG montages. https://www.selleckchem.com/products/pd0166285.html We trained and evaluated this model in a leave-one-out-dataset fashion on a large corpus of 8 heterogeneous sleep staging datasets to make it robust to demographic changes.
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