The analysis results showed that the proposed method could be able to accurately predict the concentration of glucose, TC and TG in blood. This method can instantaneous multi-component detection on whole blood.Based on the specific interaction of Ag+ and cytosine-cytosine (C-C) base mismatch and using berberine (Ber) as the fluorescent probe and Exonuclease I (Exo I) as the background fluorescence reducing tool, a label-free Exo I-assisted fluorescence aptamer sensing platform was established for the detection of silver ions with high sensitivity and selectivity. Exo I reduced the fluorescence background of the Ber/Ag+-aptamer complex to a level similar to that of Ber itself in the absence of Ag+. After introducing Ag+ into the sensing system, it induces the aptamer rich in base C to form C-Ag+-C i-motif structure which are resistant to degradation mediated by Exo I. The concentration of Ber, Ag+-aptamer, Exo I and the temperature and reaction time for Exo I were all optimized. Under the optimal experimental conditions, the detection limit of Ag+ was 4.4 nM and the linear range was from 0.0059 μM to 235.48 μM with a coefficient of determination (R2) > 0.99. Moreover, the proposed strategy had been successfully applied to the detection of Ag+ in tap water and human serum with a good recovery ranging from 88.4% to 106.9%.Rare earth-carbon dots (RE-CDs) hybrid nanomaterials with the merits of both RE and CDs have rapidly emerging as highly promising functional materials in biochemical analysis. In this work, a new kind of water-soluble RE-CDs nanocomposite (CDs@CaF2Eu3+) was developed for the ratiometric determination of doxycycline (DOX). The CDs@CaF2Eu3+ under the excitation at 365 nm displayed blue emission of CDs at 440 nm and no obvious emission of Eu3+. With the addition of DOX, substantial fluorescence quenching of the CDs at 440 nm and enhancement of Eu3+ at 613 nm were observed, resulting in a ratiometric fluorescent response toward DOX. A wide linear range from 0.1 µM to 30 µM was achieved in the detection of DOX with a lowest detection limit of 43 nM. In particular, the probe could discriminate DOX from other tetracycline antibiotics through unique fluorescence response. Moreover, we have successfully applied the method for the determination of DOX in milk and honey samples.The reaction system between the simplest Criegee intermediate, CH2OO, and the greenhouse gas CO2 has been investigated by Fourier transform microwave spectroscopy. The CH2OO-CO2 weakly bound complex was identified in the rotational spectrum, where inversion doublets due to the tunnelling motion between two equivalent configurations of the complex, with CO2 located at one side or the other side of the CH2OO plane, were observed. Using a two-state torsion-rotation Hamiltonian, a complete set of rotational and centrifugal distortion constants for both tunneling states were derived. In addition, the torsional energy difference between both states could be accurately determined, being 23.9687 MHz. The non-observation of the cycloaddition reaction product is in agreement with our ab initio calculations and with previous results that concluded that the reactivity of CIs toward CO2 is measured to be quite limited.The dose of administered chemotherapy drugs is crucial to determine due to the potential for efficient or adverse outcomes for cancer patients. To date, no user-friendly and low-cost method of doxorubicin (DOX) detection using nontoxic and biodegradable materials has been reported. For this reason, in this work, we have developed for the first time a nanofiber-based sensing platform for sensitive and on-site DOX assay in just 10 min. This is obtained thanks to printable, porosity and embeddability features of electrospun nanofibrous films (ENFFs) combined with nitrogen and sulfur co-doped carbon dots (NS-CDs) as sensing probes. The assay was done by just pipetting analyte on the hydrophilic spots of the fabricated photoluminescence water-stable ENFFs where the color intensity was being darkened. DOX quenched NS-CDs fluorescence onto ENFFs through inner filter effect. The developed sensor was either coupled with smartphone technology to provide miniaturized, portable and easy-to-use device or an ordinary spectrofluorimeter for solid-state sensing applications (detection limit of 5.4 nM). Moreover, applicability of the designed sensor was evaluated in human serum with satisfactory recoveries. It is more interesting that the fabricated NS-CDs/ENF scaffolds have a high potential to detect the intracellular DOX to enhance cell proliferation leading to be considered as a multimodal tool in biomedical research and clinical diagnostics. This study aimed to examine the reliability and validity of a newly developed Asthma Numeracy Test (ANT) and to make it available in Arabic. Patients with asthma who were ≥18 years were seen in 3 outpatient primary care or respiratory medicine clinics in the United Arab Emirates. They completed the ANT of 10 questions assessing participant arithmetic computation, meaning of percentages, estimation, and problem solving. Each question was worth 1 point, giving a total score of 10. https://www.selleckchem.com/products/pp2.html The ANT was forward and back translated to Arabic and English, respectively, by independent legal translators and piloted on 15 participants. Convergent validity was tested by comparing the ANT with the Asthma Knowledge Test (AKT) scores, knowledge of inhaled medications, and practical inhaler technique using Pearson's correlation coefficients. The average ANT score achieved by 150 participants was 6.47 ± 2.09; 25% and 45% scored ≤4.0 and 6.0, respectively. Correlation between ANT and AKT and knowledge of inhaled medications were positive, r= .22 and r= .16, P < .05, respectively. No correlation with participants' practical inhaler technique was noted. ANT was positively associated with participant educational attainment and negatively with emergency room visits. A new short and easy-to-administer test of asthma numeracy has been developed and found to be valid and reliable. It may be used to assess numeracy levels of patients with asthma and consequently develop and evaluate targeted interventions designed to improve patient care outcomes. The test is available in English and Arabic. A new short and easy-to-administer test of asthma numeracy has been developed and found to be valid and reliable. It may be used to assess numeracy levels of patients with asthma and consequently develop and evaluate targeted interventions designed to improve patient care outcomes. The test is available in English and Arabic.