Rechargeable aqueous Zn-ion batteries (ZIBs) have gained great attention due to their high safety and the natural abundance of Zn. Unfortunately, the Zn metal anode suffers from dendrite growth due to nonuniform deposition during the plating/stripping process, leading to a sudden failure of the batteries. Herein, Cu coated Zn (Cu-Zn) was prepared by a facile pretreatment method using CuSO4 aqueous solution. The Cu coating transformed into an alloy interfacial layer with a high affinity for Zn, which acted as a nucleation site to guide the uniform Zn nucleation and plating. As a result, Cu-Zn demonstrated a cycling life of up to 1600 h in the symmetric cells and endowed a stable cycling performance with a capacity of 207 mAh g-1 even after 1000 cycles in the full cells coupled with a V2O5-based cathode. This work provides a simple and effective strategy to enable uniform Zn deposition for improved ZIBs.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a pro-apoptotic protein showing broad biological functions. Data from animal studies indicate that TRAIL may possibly contribute to the pathophysiology of cardiomyopathy, atherosclerosis, ischemic stroke and abdominal aortic aneurysm. It has been also suggested that TRAIL might be useful in cardiovascular risk stratification. This systematic review aimed to evaluate whether TRAIL is a risk factor or risk marker in cardiovascular diseases (CVDs) focusing on major adverse cardiovascular events. Two databases (PubMed and Cochrane Library) were searched until December 2020 without a year limit in accordance to the PRISMA guidelines. A total of 63 eligible original studies were identified and included in our systematic review. Studies suggest an important role of TRAIL in disorders such as heart failure, myocardial infarction, atrial fibrillation, ischemic stroke, peripheral artery disease, and pulmonary and gestational hypertension. Most evidence associates reduced TRAIL levels and increased TRAIL-R2 concentration with all-cause mortality in patients with CVDs. It is, however, unclear whether low TRAIL levels should be considered as a risk factor rather than a risk marker of CVDs. Further studies are needed to better define the association of TRAIL with cardiovascular diseases.Accurate detection of malignant transformation and risk-stratification of intraductal papillary mucinous neoplasms (IPMN) has remained a diagnostic challenge. Preliminary findings have indicated a promising role of positron emission tomography combined with computed tomography and 18F-fluorodeoxyglucose (18F-FDG-PET/CT) in detecting malignant IPMN. Therefore, the aim of this model-based economic evaluation was to analyze whether supplemental FDG-PET/CT could be cost-effective in patients with IPMN. Decision analysis and Markov modeling were applied to simulate patients' health states across a time frame of 15 years. CT/MRI based imaging was compared to a strategy with supplemental 18F-FDG-PET/CT. Cumulative costs in US-$ and outcomes in quality-adjusted life years (QALY) were computed based on input parameters extracted from recent literature. The stability of the model was evaluated by deterministic sensitivity analyses. In the base-case scenario, the CT/MRI-strategy resulted in cumulative discounted costs of USD $106,424 and 8.37 QALYs, while the strategy with supplemental FDG-PET/CT resulted in costs of USD $104,842 and a cumulative effectiveness of 8.48 QALYs and hence was cost-saving. A minimum specificity of FDG-PET/CT of 71.5% was required for the model to yield superior net monetary benefits compared to CT/MRI. This model-based economic evaluation indicates that supplemental 18F-FDG-PET/CT could have a favorable economic value in the management of IPMN and could be cost-saving in the chosen setting. Prospective studies with standardized protocols for FDG-PET/CT could help to better determine the value of FDG-PET/CT.Laboratory experiments have shown higher oil recovery with nanoparticle (NPs) flooding. Accordingly, many studies have investigated the nanoparticle-aided sweep efficiency of the injection fluid. The change in wettability and the reduction of the interfacial tension (IFT) are the two most proposed enhanced oil recovery (EOR) mechanisms of nanoparticles. Nevertheless, gaps still exist in terms of understanding the interactions induced by NPs that pave way for the mobilization of oil. This work investigated four types of polymer-coated silica NPs for oil recovery under harsh reservoir conditions of high temperature (60 ∘C) and salinity (38,380 ppm). Flooding experiments were conducted on neutral-wet core plugs in tertiary recovery mode. Nanoparticles were diluted to 0.1 wt.% concentration with seawater. The nano-aided sweep efficiency was studied via IFT and imbibition tests, and by examining the displacement pressure behavior. https://www.selleckchem.com/products/bmn-673.html Flooding tests indicated incremental oil recovery between 1.51 and 6.13% of the original oil in place (OOIP). The oil sweep efficiency was affected by the reduction in core's permeability induced by the aggregation/agglomeration of NPs in the pores. Different types of mechanisms, such as reduction in IFT, generation of in-situ emulsion, microscopic flow diversion and alteration of wettability, together, can explain the nano-EOR effect. However, it was found that the change in the rock wettability to more water-wet condition seemed to govern the sweeping efficiency. These experimental results are valuable addition to the data bank on the application of novel NPs injection in porous media and aid to understand the EOR mechanisms associated with the application of polymer-coated silica nanoparticles.A hydroxypolyamide (HPA) manufactured from 2,2-bis(3-amino-4-hydroxy phenyl)-hexafluoropropane (APAF) diamine and 5'-terbutyl-m-terphenyl-4,4''-dicarboxylic acid chloride (tBTpCl), and a copolyimide produced by stochiometric copolymerization of APAF and 4,4'-(hexafluoroisopropylidene) diamine (6FpDA), using the same diacid chloride, were obtained and used as polymeric matrixes in mixed matrix membranes (MMMs) loaded with 20% (w/w) of two porous polymer networks (triptycene-isatin, PPN-1, and triptycene-trifluoroacetophenone, PPN-2). These MMMs, and also the thermally rearranged membranes (TR-MMMs) that underwent a thermal treatment process to convert the o-hydroxypolyamide moieties to polybenzoxazole ones, were characterized, and their gas separation properties evaluated for H2, N2, O2, CH4, and CO2. Both TR process and the addition of PPN increased permeability with minor decreases in selectivity for all gases tested. Excellent results were obtained, in terms of the permeability versus selectivity compromise, for H2/CH4 and H2/N2 separations with membranes approaching the 2008 Robeson's trade-off line.
Rechargeable aqueous Zn-ion batteries (ZIBs) have gained great attention due to their high safety and the natural abundance of Zn. Unfortunately, the Zn metal anode suffers from dendrite growth due to nonuniform deposition during the plating/stripping process, leading to a sudden failure of the batteries. Herein, Cu coated Zn (Cu-Zn) was prepared by a facile pretreatment method using CuSO4 aqueous solution. The Cu coating transformed into an alloy interfacial layer with a high affinity for Zn, which acted as a nucleation site to guide the uniform Zn nucleation and plating. As a result, Cu-Zn demonstrated a cycling life of up to 1600 h in the symmetric cells and endowed a stable cycling performance with a capacity of 207 mAh g-1 even after 1000 cycles in the full cells coupled with a V2O5-based cathode. This work provides a simple and effective strategy to enable uniform Zn deposition for improved ZIBs.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a pro-apoptotic protein showing broad biological functions. Data from animal studies indicate that TRAIL may possibly contribute to the pathophysiology of cardiomyopathy, atherosclerosis, ischemic stroke and abdominal aortic aneurysm. It has been also suggested that TRAIL might be useful in cardiovascular risk stratification. This systematic review aimed to evaluate whether TRAIL is a risk factor or risk marker in cardiovascular diseases (CVDs) focusing on major adverse cardiovascular events. Two databases (PubMed and Cochrane Library) were searched until December 2020 without a year limit in accordance to the PRISMA guidelines. A total of 63 eligible original studies were identified and included in our systematic review. Studies suggest an important role of TRAIL in disorders such as heart failure, myocardial infarction, atrial fibrillation, ischemic stroke, peripheral artery disease, and pulmonary and gestational hypertension. Most evidence associates reduced TRAIL levels and increased TRAIL-R2 concentration with all-cause mortality in patients with CVDs. It is, however, unclear whether low TRAIL levels should be considered as a risk factor rather than a risk marker of CVDs. Further studies are needed to better define the association of TRAIL with cardiovascular diseases.Accurate detection of malignant transformation and risk-stratification of intraductal papillary mucinous neoplasms (IPMN) has remained a diagnostic challenge. Preliminary findings have indicated a promising role of positron emission tomography combined with computed tomography and 18F-fluorodeoxyglucose (18F-FDG-PET/CT) in detecting malignant IPMN. Therefore, the aim of this model-based economic evaluation was to analyze whether supplemental FDG-PET/CT could be cost-effective in patients with IPMN. Decision analysis and Markov modeling were applied to simulate patients' health states across a time frame of 15 years. CT/MRI based imaging was compared to a strategy with supplemental 18F-FDG-PET/CT. Cumulative costs in US-$ and outcomes in quality-adjusted life years (QALY) were computed based on input parameters extracted from recent literature. The stability of the model was evaluated by deterministic sensitivity analyses. In the base-case scenario, the CT/MRI-strategy resulted in cumulative discounted costs of USD $106,424 and 8.37 QALYs, while the strategy with supplemental FDG-PET/CT resulted in costs of USD $104,842 and a cumulative effectiveness of 8.48 QALYs and hence was cost-saving. A minimum specificity of FDG-PET/CT of 71.5% was required for the model to yield superior net monetary benefits compared to CT/MRI. This model-based economic evaluation indicates that supplemental 18F-FDG-PET/CT could have a favorable economic value in the management of IPMN and could be cost-saving in the chosen setting. Prospective studies with standardized protocols for FDG-PET/CT could help to better determine the value of FDG-PET/CT.Laboratory experiments have shown higher oil recovery with nanoparticle (NPs) flooding. Accordingly, many studies have investigated the nanoparticle-aided sweep efficiency of the injection fluid. The change in wettability and the reduction of the interfacial tension (IFT) are the two most proposed enhanced oil recovery (EOR) mechanisms of nanoparticles. Nevertheless, gaps still exist in terms of understanding the interactions induced by NPs that pave way for the mobilization of oil. This work investigated four types of polymer-coated silica NPs for oil recovery under harsh reservoir conditions of high temperature (60 ∘C) and salinity (38,380 ppm). Flooding experiments were conducted on neutral-wet core plugs in tertiary recovery mode. Nanoparticles were diluted to 0.1 wt.% concentration with seawater. The nano-aided sweep efficiency was studied via IFT and imbibition tests, and by examining the displacement pressure behavior. https://www.selleckchem.com/products/bmn-673.html Flooding tests indicated incremental oil recovery between 1.51 and 6.13% of the original oil in place (OOIP). The oil sweep efficiency was affected by the reduction in core's permeability induced by the aggregation/agglomeration of NPs in the pores. Different types of mechanisms, such as reduction in IFT, generation of in-situ emulsion, microscopic flow diversion and alteration of wettability, together, can explain the nano-EOR effect. However, it was found that the change in the rock wettability to more water-wet condition seemed to govern the sweeping efficiency. These experimental results are valuable addition to the data bank on the application of novel NPs injection in porous media and aid to understand the EOR mechanisms associated with the application of polymer-coated silica nanoparticles.A hydroxypolyamide (HPA) manufactured from 2,2-bis(3-amino-4-hydroxy phenyl)-hexafluoropropane (APAF) diamine and 5'-terbutyl-m-terphenyl-4,4''-dicarboxylic acid chloride (tBTpCl), and a copolyimide produced by stochiometric copolymerization of APAF and 4,4'-(hexafluoroisopropylidene) diamine (6FpDA), using the same diacid chloride, were obtained and used as polymeric matrixes in mixed matrix membranes (MMMs) loaded with 20% (w/w) of two porous polymer networks (triptycene-isatin, PPN-1, and triptycene-trifluoroacetophenone, PPN-2). These MMMs, and also the thermally rearranged membranes (TR-MMMs) that underwent a thermal treatment process to convert the o-hydroxypolyamide moieties to polybenzoxazole ones, were characterized, and their gas separation properties evaluated for H2, N2, O2, CH4, and CO2. Both TR process and the addition of PPN increased permeability with minor decreases in selectivity for all gases tested. Excellent results were obtained, in terms of the permeability versus selectivity compromise, for H2/CH4 and H2/N2 separations with membranes approaching the 2008 Robeson's trade-off line.
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