OBJECTIVES The objective was to describe (1) the type, (2) the amount of use, and (3) the time of usage of electronic devices, for school days and weekends, as well as its impact on adolescents' sleep quality. DESIGN A cross-sectional study using hierarchical regressions accounting for confounding sleep-related variables was used. SETTING The participants were from six public schools in Porto Alegre, Brazil. PARTICIPANTS The participants included 177 students of both sexes aged between 11 and 18 years. MEASUREMENTS An electronic usage diary assessed the span of time during which the electronic device was used (separated by "TV and computer monitors", "tablets, e-readers and portable video games," and "cell phones") for school days and weekends. The Munich Chronotype Questionnaire was used to assess sleep duration, midpoint of sleep, and social jetlag. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. RESULTS Greater nighttime use and last time of use of cell phones at night are associated with worse sleep quality in univariate analyses. A hierarchical regression model shows that poor sleep quality associates with shorter sleep duration on school days and with a delayed midpoint of sleep on weekends. Electronic device use did not reach statistical significance in the regression model with confounding factors. CONCLUSIONS Adequate sleep duration is imperative to maintain a good sleep quality on school days, independently of the use of cell phones. It is important to underpin the need for evaluation of sleep phase and chronotype in future research on the topic aiming to elucidate its relationship with electronic use on school-free days. OBJECTIVE Early-stage romantic involvement may resemble hypomania in its manifestation on behavioral, physiological, and psychological levels. Previous research suggests that self-reported sleep duration may diminish as a result of falling in love during adolescence. We investigated how feelings of infatuation are related to subjective and objective measures of sleep duration, quality, and timing. METHODS 1374 adolescents (66% girls; mean age 16.9, SD=0.6 years) selected from the population register responded to online questionnaires regarding romantic love, mental well-being, and sleep behavior. A subsample (n=309) underwent a week-long actigraphy measurement (GENEActiv Original). We compared the sleep duration, quality, and timing of those who reported being in the early stages of love to those who were not. RESULTS 11% of all participants reported being in the early stages of romantic love. Those girls and boys who were in love had higher scores of depression and anxiety than others. Girls who were in love reported poorer sleep quality, later sleep timing, and shorter sleep duration both on weekdays (mean difference 32 minutes, p≤0.001) and at weekends (15 minutes, p=0.037) than those who were not in love. Actigraphy measurements were similar (sleep duration mean difference 27 minutes, p=0.04). CONCLUSIONS We conclude that romantic love is one further cause for short or poor quality sleep in girls and may relate to symptoms of depression and anxiety in both sexes. https://www.selleckchem.com/products/ha130.html However, feelings of infatuation contain important developmental lessons. BACKGROUND & AIMS Uncertainty still exists on the impact of low to moderate consumption of different drink types on population health. We therefore investigated the associations of different drink types in the form of beer/cider, champagne/white wine, red wine and spirits with various health outcomes. METHODS Over 500,000 participants were recruited to the UK Biobank cohort. Alcohol consumption was self-reported as pints beer/cider, glasses champagne/white wine, glasses of red wine, and measures of spirits per week. We followed health outcomes for a median of 7.02 years and reported all-cause mortality, cardiovascular events, ischemic heart disease, cerebrovascular events, and cancer. RESULTS In continuous analysis after excluding non-drinkers, beer/cider and spirits intake associated with an increased risk for all-cause mortality (beer/cider hazard ratio, 1.56; 95% confidence interval, 1.45-1.68; spirits 1.47; 1.35-1.60), cardiovascular events (beer/cider 1.25; 1.17-1.33; spirits 1.25; 1.16-1.36), ischemic heart disease (beer/cider1.12; 0.99-1.26 [P = 0.056]; spirits 1.17; 1.02-1.35), cerebrovascular disease (beer/cider 1.63; 1.32-2.02; spirits 1.59; 1.25-2.02) and cancer (beer/cider 1.14; 1.05-1.24; spirits 1.14; 1.03-1.26), while both champagne/white wine and red wine associated with a decreased risk for ischemic heart disease only (champagne/white wine 0.84; 0.72-0.98; red wine 0.88; 0.77-0.99). CONCLUSIONS Our findings do not support the notion that alcohol from any drink type is beneficial to health. Consuming low levels of beer/cider and spirits already associated with an increased risk for all health outcomes, while wine showed opposite protective relationships only with ischemic heart disease. BACKGROUND & AIMS Although the mechanisms by which statins promote muscle disorders remain unclear, supplementation with dietary antioxidants may mitigate statins' side effects. This study aimed to investigate whether the consumption of Brazil nuts modulates serum creatine kinase (CK) activity in patients regularly using statins. METHODS The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients in regular use of statins were divided according to CK activity levels (G1 increased or G2 normal) and received one unit of Brazil nut daily for 3 months. Body composition, blood selenium (Se) concentrations, erythrocyte glutathione peroxidase (GPX) activity, oxidative stress parameters, and CK activity were evaluated before and after supplementation. RESULTS In both groups, supplementation with one Brazil nut daily for 3 months contributed to achieve decreased levels of CK activity in serum, with positive changes in plasma and erythrocyte Se concentrations (p  less then  0.0001), and increased levels of GPX activity. Among the parameters related to curbing of oxidative stress, we observed reduced levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in both groups after supplementation. We also found a moderately negative association between CK and GPX activity (r = -41; p  less then  0.02). Expression of selenoproteins GPX1, SELENOP, and SELENON after Brazil nut supplementation was unchanged. CONCLUSION Brazil nut consumption enhanced the control of CK activity by improving oxidative stress biomarkers in patients using statins but did not modulate mRNA expression of selenoproteins.