Together with the antioxidant inhibition response and distinctive lipid metabolic reprogramming by heat stress, this oxidative damage was amplified to induce tumor ferroptosis and achieve sufficient antitumor effects. Importantly, we confirmed that ACSBG1, an acyl-CoA synthetase, was the key pro-ferroptotic factor in this heat-induced ferroptosis process. Moreover, knockout of this gene could realize cancer cell death fate conversion from ferroptosis to non-ferroptotic death. This work provides mechanistic insights and practical strategies for heat-triggered ferroptosis in situ to reduce the potential side effects of direct ferroptosis inducers and highlights the key factor in regulating cell fate under heat stress.Cervical disc arthroplasty (CDA) is a well known treatment for single level cervical disc degeneration. In multi level disc degeneration anterior cervical disc fusion (ACDF) is often combined with a CDA. In this hybrid construction, motion is preserved at the level of the CDA. This will give less stiffness in the neck and decreases stress at the adjacent level. However, there is a lack of literature about the long term efficacy, safety and complication rate of CDA in hybrid constructions. In this article we present two cases of spontaneous destruction of a M6-C prosthesis in a hybrid construction 5 years after surgery. One reason seems to be the polymer sheath who is used in the M6 prosthesis. Degradation of this sheath causes foreign body reactions with osteolysis in the vertebral bodies. However, the increased mechanical loading at the adjacent levels on the CDA due to the fused vertebrae could also be one of the reasons.In the absence of prosthetic arthroplasty offering good results for the treatment of wrist osteoarthritis, we studied the arthrodesis of three carpal bones (lunate - hamate - capitate) completed by triquetrum and scaphoid excision in the presence of Scapholunate Advanced Collapse (SLAC) or Scaphoid Nonunion Advanced Collapse (SNAC) stage II or III. Clinical data on eight patients between the ages of 32 and 61 years at an average of 29 months after surgery was analyzed. Seven patients reached fusion with a carpal height ratio of 0.39. These arc of dorsal-palmar flexion (DPF) attended 54° and the arc of radio-ulnar deviation (RUD) 29° using the optoelectronic stereophotogrammetry system. The mean polar radius (R) was 14.5° and the envelope shape coefficient (K) was 1.66. This operation could be considered as an alternative for the treatment of patients suffering of SNAC or SLAC stage II and III. Type of study/level of evidence Therapeutic IV.Clinical results of endoscopic distal biceps tendon repair have been shown to be comparable to open techniques in small series. https://www.selleckchem.com/products/alw-ii-41-27.html This study evaluates safety and accuracy of the endoscopic technique. Sixteen fresh-frozen paired cadaveric upper extremities were used. The distal biceps tendons were cut and then repaired with the classic single incision bone button technique. Eight were done through an open technique, and eight were repaired endoscopically. Safety and accuracy were assessed by comparing the distance of the repair to neurovascular structures as well as the distance of the bone tunnel to the native biceps insertion. Paired t-tests were used to compare measurements. Significance level was set at p=0.05. There were no significant differences between the open and endoscopic groups, for any of the anatomic measurements. The ulnar artery was the closest neurovascular structure to the tunnel, with an average of 1 mm. The radial and recurrent radial arteries were located at 3 and 19 mm respectively. The median nerve was an average 10 mm from the tunnel, and both the SBRN and PIN at 12 mm. The distance between the PIN and the endobutton at the posterior side of the radius was an average 6 mm. There were no significant differences in variance between both groups related to the placement of the tunnel relative to the native biceps insertion. The single incision endoscopic-assisted technique of distal biceps repair can be performed consistently and with no added risk to neurovascular structures when compared to the classic open technique.The purpose of the study is to evaluate the accuracy of detecting subscapularis tendon tears on different imaging modalities in comparison with surgical findings. In addition, the accuracy of long head of biceps tendon pathology in assisting the diagnosis of a subscapularis tear was evaluated. Retrospectively, 336 patients who underwent surgery in the UZ Brussel for rotator cuff pathology and had pre-operative imaging at the hospital were included. Pathology of the subscapularis tendon and the long head of biceps tendon on imaging modalities was compared to arthroscopic and/or open surgery findings. 111 of the 336 patients (33.0%) had a subscapularis tear diagnosed during surgery. None of the imaging modalities reaches the cut-off weighted kappa value (k) for substantial agreement of 0.61. Magnetic re- sonance imaging and magnetic resonance arthro- graphy have the highest k of 0.288, indicating minimal agreement with arthroscopy. Computed tomography arthrography (k = 0.167) and ultrasound (k = 0.173) shows both no agreement. Biceps instability was significantly correlated with a subscapularis tear, but the negative predictive value was always higher than the positive predictive value on ultrasound, magnetic resonance arthrography and computed tomography arthrography. The negative predictive value for detection of full thickness tears is as high as 96.2% on magnetic resonance arthrography. Accurate imaging diagnosis in daily practice of subscapularis tendon tears remains a challenge with the best results for magnetic resonance arthrography. The value of biceps instability lies in its negative predictive value rather than its positive predictive value.Os acromiale is due to a defect of fusion of the different ossification centers of the acromion. It is a common cause of shoulder pain that should be evoked in the differential diagnosis of the sub-acromial conflict. CT scan or magnetic resonance are therefore often helpful to confirm the diagnosis. Conservative treatment is the first-line management but various surgical techniques are described in case of initial treatment failure. In this context, new arthroscopic techniques offer encouraging results. This article overviews the key points of pathophysiology, clinical manifestations, para-clinical studies and treatment of os acromiale.