15-.55). In depressed patients, on average, negative implicit self-representations appeared to be weaker or less efficiently processed relative to positive self-representations; elicited greater recruitment of frontoparietal task network regions; and, according to computational modeling of trial-by-trial data, were driven primarily by differential efficiency of information accumulation for negative and positive attributes. Greater degree of discrepancy between implicit and explicit self-worth predicted depression severity. Overall, these IATs show potential utility in understanding heterogeneous substrates of depression but leave substantial room for improvement. The observed clinical, neural, and computational correlates of implicit self-associations offer novel insights into a simple computer-administered task in a clinical population and point toward heterogeneous depression mechanisms and treatment targets. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Exposure to adverse childhood experiences (ACEs) is prevalent and confers risk for psychopathology later in life. Approaches to understanding the impact of ACEs on development include the independent risk approach, the Dimensional Model of Adversity and Psychopathology (DMAP) distinguishing between threat and deprivation events, and the cumulative risk approach. The present research provides an empirical confirmation of DMAP and a comparison of these three approaches in predicting internalizing and externalizing symptoms in youth. In Study 1, mental health professionals (N = 57) rated ACEs as threat or deprivation events. These ratings were used to create composites to represent the DMAP approach in Study 2. With cross-sectional and longitudinal data from children and adolescents in state custody (N = 23,850), hierarchical linear regression analyses examined independent risk, DMAP, and cumulative risk models in predicting internalizing symptoms, disinhibited externalizing symptoms, and antagonistic externalizing symptoms. All three approaches produced significant models and revealed associations between exposure to ACEs and symptoms. Individual risk accounted for significantly more variance in symptoms than cumulative risk and DMAP. Cumulative risk masked differential associations between ACEs and psychological symptoms found in the individual risk and DMAP approaches. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Paranoia is the exaggerated belief that harm will occur and is intended by others. Although commonly framed in terms of attributing malicious intent to others, recent work has explored how paranoia also affects social decision-making, using economic games. Previous work found that paranoia is associated with decreased cooperation and increased punishment in the Dictator Game (where cooperating and punishing involve paying a cost to respectively increase or decrease a partner's income). These findings suggest that paranoia might be associated with variation in subjective reward from positive and/or negative social decision-making, a possibility we explore using a preregistered experiment with U.S.-based participants (n = 2,004). Paranoia was associated with increased self-reported enjoyment of negative social interactions and decreased self-reported enjoyment of prosocial interactions. More paranoid participants attributed stronger harmful intent to a partner. Harmful intent attributions and the enjoyment of negative social interactions positively predicted the tendency to pay to punish the partner. Cooperation was positively associated with the tendency to enjoy prosocial interactions and increased with participant age. There was no main effect of paranoia on tendency to cooperate in this setting. We discuss these findings in light of previous research. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Internalizing (anxiety and depressive) disorders, and the symptoms that comprise them, are known for being chronic and recurrent. https://www.selleckchem.com/products/sw033291.html Neuroticism, reflecting dispositional tendencies toward negative affect, is a personality trait that bears durable cross-sectional and prospective associations with internalizing symptoms. There are also indications that extraversion, consisting of tendencies such as the heightened experience of positive emotion, is associated with these symptoms. Some investigators have posited that the experience of internalizing symptoms leaves residual effects, or scars, on personality traits, with the effect of raising risk of symptom reexacerbation. In the present study, we compare vulnerability and scar effects in a sample of older adolescents (N = 606) at risk for the development of internalizing disorders. Anxiety and depressive symptoms were assessed annually, as were neuroticism, extraversion, and other trait-like cognitive vulnerabilities. Cross-lagged panel models compared the relative strength of vulnerability and scar effects, revealing support for vulnerability effects but little evidence of scar effects. The results also showed that whatever scar effects might be present are weaker than vulnerability effects in the case of neuroticism. These findings underscore the importance of personality vulnerability for internalizing symptom risk by suggesting that neuroticism vulnerability is stronger than any lasting scars the experience of internalizing symptoms produce. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The Constitution of the Iroquois Nation states that we should "look and listen for the welfare of the whole people and have always in view not only the present, but also the coming generations." The excellent intergenerational longitudinal studies represented here help us better understand patterns of behaviors across generations. Collectively, these studies provide a pathway for future research on contexts and trends in substance use, research on age of onset among early generations, and research related to epigenetics to improve prevention interventions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).Epidemiologic research serves as an important foundation for intervention research. In this way, it can contribute to vast improvements in public health. However, to fully capitalize on what is learned through epidemiology, collaborations must ensure the translation of epidemiologic findings into both treatment and prevention interventions. This commentary suggests some ways in which epidemiology can inform intervention research and how intervention research can be backtranslated so that epidemiological studies are designed to better inform intervention design. The commentary does this by using as examples the original contributions in this special section on the intergenerational transmission of cannabis use. These studies identify several ways in which epidemiology can inform intervention and discuss mechanisms of risk transmission from one generation to the next, such as parental monitoring, parent norms around substance use or parenting strategies, poor inhibitory control, or perceptions of harm from substance use.