RESULTS For substantiated child maltreatment referrals, 90 % of the total between-area variation in risk is captured by the shared component, while for unsubstantiated child maltreatment referrals, the shared component was 88 %. The correlation between substantiated and unsubstantiated risks of child maltreatment referrals was .80. These risks were higher in neighborhoods with low levels of socioeconomic status, higher immigrant concentration, public disorder and crime. CONCLUSIONS Child maltreatment referrals, regardless of whether substantiated or unsubstantiated, overlap in the same disadvantaged neighborhoods. This suggests that in these neighborhoods, families are at a higher risk of being investigated by child protective services suggesting a potential reporting bias. INTRODUCTION Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between BET bromodomains and Ac-K of histone tails. With a molecular imaging probe, noninvasive imaging such as positron emission tomography (PET) can visualize the distribution and roles of BET family proteins in vivo and enlighten our understanding of BET protein function in both healthy and diseased tissue. METHODS We radiolabeled the potent BET inhibitor INCB054329 by N-methylation to make [11C]PB003 as a BET PET radiotracer. The bioactivity evaluation of unlabeled PB003 in vitro was performed to confirm its binding affinity for BRDs, then the PET/CT imaging in rodents was performed to evaluate the bioactivity of [11C]PB003 in vivo. RESULTS In our in vitro evaluation, PB003 showed a high BET binding affinity for BRDs (Kd = 2 nM, 1.2 nM, and 1.2 nM for BRD2, BRD3, and BRD4, respectively). In vivo PET/CT imaging demonstrated that [11C]PB003 has favorable uptake with appropriate kinetics and distributions in main peripheral organs. Besides, the blockade of [11C]PB003 binding was found in our blocking study which indicated the specificity of [11C]PB003. However, the BBB penetration and brain uptake of [11C]PB003 was limited, with only a maximum 0.2% injected dose/g at ~2 min post-injection. CONCLUSION The imaging results in rodents in vivo demonstrate that [11C]PB003 binds to BET with high selectivity and specificity and has favorable uptake in peripheral organs. However, the low brain uptake of [11C]PB003 limits the visualization of brain regions indicating the efforts are still needed to discover the new BET imaging probes for brain visualization. The singlet fission (SF) process, which is involved in organic solar cell, is a spin allowed and extremely fast internal conversion process by which a photo-excited singlet exciton produces two triplets. To accelerate this fission and to increase the efficiency of solar cell, designing of new materials/molecules is an interesting area of research and our current interest. Several alternate hydrocarbons of the acene series and their derivatives with structural variety are desirable for this purpose. Therefore, we have theoretically modeled and investigated different substituted hexacenes in detail. Different electron donating groups (EDGs) as well as electron withdrawing groups (EWGs) and few groups of other varieties are chosen for site-specific monosubstitution to the hexacene ring for manipulation of their excited singlet-triplet energy levels and thereby to match the SF driving force (Δ) and triplet-triplet annihilation (TTA) deactivation force (Ω). The geometries, electronic structures, frontier molecular orbital (FMO) energies, optimization of excited state and calculation of Δ and Ω of the substituted hexacenes are investigated with Time Dependent Density functional theory (TDDFT) method using B3LYP/6-31G∗ basis set. After a detail theoretical analysis on sixty five (65) hexacene derivatives, the δ-triisopropylsilylethynyl (-TIPS) hexacene and β-NO2 hexacene are predicted to exhibit good SF characteristics. The stability of Gemcitabine (Gem) anticancer drug on the hexagonal boron nitride (h-BN) and functionalized h-BN with polyethylene glycol (PEG-h-BN) as drug delivery carriers (DDSs) is investigated. The density functional theory (DFT) calculations, molecular dynamics (MD) simulation and Metadynamics simulations are used to study the nature of h-BN-Gem interactions as well as the role of PEG group to increase the efficiency of the DDS. The results of DFT calculations reveal that the drug physisorbed on the h-BN surface through the formation of π-π stacking with an adsorption energy range -15.08 kJ/mol to -90.74 kJ/mol. Moreover, the obtained results show that the grafting the PEG group to h-BN cause to π-π stacking is reinforced by the formation of strong HBs and leads to increase adsorption energy about 20%. There is a good agreement between DFT calculation and MD simulation results. Also, The MD simulations demonstrate in adsorption of the drug on the carriers, the contribution of van der Waals energy is more than the electrostatic energy. https://www.selleckchem.com/products/mz-1.html The well-tempered metadynamics simulations are performed to find the free energy surface (FES) of the studied systems. The FES for the Gem/h-BN and Gem/PEG-h-BN interfaces show the global minimum at around 3.0-6.0 Å and 1.2 Å, respectively. The orientational analysis proves that the global minimum can be related to the formation of π-π stacking and HB interaction. With the increasing awareness about the contamination of the aquatic environment by pharmaceuticals, there is a growing need to study their adverse effects on aquatic organisms. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), whose wide use contributes for its presence in freshwater ecosystems, increasing the probability of causing deleterious changes in aquatic biota. This study evaluated possible oxidative stress effects in Danio rerio embryos and larvae when exposed to a range of ecologically relevant concentrations of diclofenac. It was possible to conclude that diclofenac caused a scenario of oxidative stress, since all tested toxicological parameters were responsive to the drug. In general, diclofenac caused not only significant anti-oxidant adaptive responses for most levels of exposure, but also peroxidative damage. This work evidenced the responsiveness of D. rerio towards diclofenac in environmentally relevant concentrations, which shows that these organisms might face a scenario of oxidative stress in their natural habitat.