The age-standardized incidence and mortality rates increased by 3.3% and 1.0% per year during 2000-2015, and were projected to increase by more than 11% until 2030. Changes in risk and demographic factors between 2015 and 2030 in cases are predicted to increase by approximately 13.3% and 22.9%, whereas deaths are predicted to increase by 13.1% and 40.9%, respectively. The incidence and mortality of breast cancer continue to increase in China. There are no signs that this trend will stop by 2030, particularly in rural areas. Effective breast cancer prevention strategies are therefore urgently needed in China. The incidence and mortality of breast cancer continue to increase in China. There are no signs that this trend will stop by 2030, particularly in rural areas. Effective breast cancer prevention strategies are therefore urgently needed in China.Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (BBB). Fortunately, recent endeavors using gold-based nanomaterials (GBNs) have indicated the potential of these materials to cross the BBB. Therefore, GBNs might be an attractive therapeutic strategy against brain cancer. Herein, we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment. Furthermore, the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized, with an emphasis on the mechanism of their effective BBB penetration. Finally, the challenges and future outlook in using GBNs for brain cancer treatment are discussed. We hope that this review will spark researchers' interest in constructing more powerful nanoplatforms for brain disease treatment.Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. SARS-CoV-2 transmission on different levels showed that the cold and dry climate, hot wind and relative humid wind, maximum wind speed, turbulent wind, intensified recirculating flow were causing transmission higher than factors. The role of environmental factors described in Ayurveda like air, water, soil, season, frequent earthquakes, sunlight exposure, frequent thunderstorm with lightening, and factors from arthropods were revalidated in perspective of COVID-19 transmission. The authors searched the information regarding epidemic diseases in Ayurveda textbooks. Pubmed, Science Direct, Wikipedia, Elsevier, Lancet, and Springer were approached for the latest knowledge relating to SARS-CoV-2 and COVID-19. Google Scholar search engine was thoroughly checked upon for scientific evidence regarding the Ayurveda drugs. Various environmental factors like soil, air, water, frequent earthquake disasters, wildlife animals, aquatic birds, space, inevitable disastrous factors, weather or seasonal hazards, violent thunderstorm with lightning, intermediate hosts, sunlight exposure etc. were considered for their role in the genesis of the disease. The Ayurvedic concepts behind the etiology and development of epidemics are the same as modern epidemiological theories. The mysteries of many aspects of the current pandemic might be deciphered by traditional medicine knowledge and thus adding upon to the integrative medicine concept. Traffic accidents in pedestrians is one of the most important causes of death. Understanding the status quo and identification of effective factors are necessary for the management and planning of efficient training interventions in the prevention of traffic accidents for pedestrians. Hence, the present study aimed to determine the predictors of safe road-crossing behavior among female high school students of Shahr-e Kord. The present research was a descriptive-analytical study which was conducted on 347 female high school students of Shahr-e Kord in the academic year 2016-2017. The participants were selected using random sampling method and the required data were collected through a standard questionnaire based on the theory of planned behavior. The obtained data were statistically analyzed using Pearson correlation test and regression analysis. The mean score of participants on the adoption of safe road-crossing behavior was equal to 57.06±14.74. Among the independent variables of this study, the lowest and the highest scores were related to behavioral intention and outcome expectancy, respectively. The results of multiple regression test showed that behavioral beliefs, outcome expectancy, compliance motivation and behavioral intention are predictors of the adoption of safe road-crossing behavior. In total, these constructs were able to predict 25.8% of behavioral changes. Based on the study findings, the theory of planned behavior can be considered an appropriate framework for designing training interventions in order to improve students' road-crossing behavior. Based on the study findings, the theory of planned behavior can be considered an appropriate framework for designing training interventions in order to improve students' road-crossing behavior. Hyperinsulinemia increases the risk factor ofdiabetes and infertility at a manifold. has several medical significances with limited reports. https://www.selleckchem.com/products/abt-199.html Hence, this study assessed the effect of on sexual-reproductive functions and distribution of insulin receptors in the hypothalamic-pituitary-testicular axis of hyperinsulinemic mice. Forty male adult mice were divided into five groups as follows control, high-fat diet (HFD)+streptozotocin (STZ), therapeutic, co-administration group type 1 (CO-AD) and probiotics. They were either simultaneously exposed to an HFD and treatment for 28days with a dose of STZ injection to induce hyperinsulinemia on day 28 or treated with for 14days, and following induction of hyperinsulinemia. Mice were subjected to a sexual behavioural test and thereafter sacrificed under euthanasia condition. Blood, brain and testes were collected for biochemical and immunohistochemical assays. Treatment with ameliorated reproductive hormones activity disruption, sexual behavioural defects, antioxidant imbalance, insulin dysregulation andlipid metabolism dysfunction following exposure toHFD+STZ when compared to the hyperinsulinemic untreated mice.