Background A large number of the world's post-stroke survivors suffers with moderate to severe disability. Long-term uncontrolled stroke risk factor led to unforeseen recurrent stroke and growing number of stroke occurrence across ages predominantly among the aging group in Malaysia. This situation has led to research works tapping into patient education especially related to the self-efficacy of understanding and taking medication appropriately. Video narratives integrated with Health Belief Model (HBM) constructs have displayed potential impact as an aide to patient education efforts. Objective This study aimed to investigate the feasibility and acceptability of study procedures based on a trial protocol of video narratives intervention among post-stroke patients. We also report the preliminary findings of video narratives on medication understanding and use self-efficacy (MUSE) and blood pressure (BP) control. Methods A parallel group randomized controlled study of a control group (without video-viewing) a patient approach were carried out with minimal challenge and adequate patient satisfaction. The video contents received good responses about its comprehension and simplicity. Moreover, an in-depth phone interview with 8 patients found the video narratives useful and inspiring. These findings also paralleled significant preliminary improvement in MUSE and systolic BP control (P less then .05). Conclusions The queries and feedback from each phase in this study had been acknowledged and thus, would be taken forward to the full randomized controlled trial (RCT). Clinicaltrial UTN1111-1201-3955, ACTRN 12618000174280.Background Borderline personality disorder (BPD) is primarily characterized by deficient emotion regulation. Impaired cognitive control over negative emotions is central to emotion dysregulation in BPD. Respective executive dysfunctions are associated with hypoactivation of prefrontal regions, and consecutive alterations of fronto-limbic network functionality. Here, we investigated the effect of increasing activity of the dorsolateral prefrontal cortex (DLPFC) with repeated transcranial direct current stimulation (tDCS) on (1) executive dysfunctions and (2) whether improving cognitive control affects emotion dysregulation and emotional processing in BPD. Methods Thirty-two patients diagnosed with BPD were randomly assigned to active stimulation (N = 16) or sham stimulation (N = 16) group in a randomized, sham-controlled, parallel-group design. They received 10 sessions of active (2 mA, 20 min, anodal left- cathodal right DLPFC) or sham tDCS over 10 days. Major executive functions, emotion regulation strategies, and emotional processing of the patients were assessed before and immediately after the intervention. Results The active stimulation group showed a significant improvement in major executive function domains. Importantly, cognitive reappraisal strategy of emotion regulation and several factors of emotional processing involved in the control of emotion significantly improved in the active stimulation group after the intervention. Factors related to emotional expression were, however, not affected. Limitations The single-blind design, absence of follow-up measures, and the intrinsically limited focality of tDCS are limitations of this study. Conclusions Increasing activity of the DLPFC improves executive functioning in BPD and improves ´cognitive control over negative emotions. Cognitive control interventions could be a potential, symptom-driven therapeutic approach in BPD.Background The specific impacts of attitudes toward aging on depressive symptoms have not been widely reported in previous studies in China. Objectives The aim is to examine the associations between attitudes toward aging, perceived social support, and depressive symptoms among older adults stratified by rural and urban dwelling. Methods This study used a cross-sectional data including 7209 participants, among which 64.6% were urban adults and 35.4% were rural adults. Several multiple liner regression models were used to analysis the data. Three social support types were analyzed as moderators of the relationship between the attitudes toward aging and depressive symptoms. Results Positive attitudes toward aging (β=-0.139, P less then 0.001), negative attitudes toward aging (β=0.284, P less then 0.001) were significantly associated with lower depressive symptoms among older Chinese adults. Support from family (β=-0.087, P less then 0.001), friends (β=-0.047, P less then 0.01) and the government (β=-0.035, P less then 0.01) were all significantly associated with urban older adults' levels of depressive symptoms. Only family support (β=-0.109, P less then 0.001) was associated with lower depressive symptoms among rural older adults'. In addition, family support buffered the effect of negative attitudes toward aging on depressive symptoms for all the older adults, while the moderation effects of support from friends and government only worked for urban elderly. Limitations A cross-sectional design is limited to establish causal associations. Conclusions Addressing depression among older adults should focus on improving attitudes toward aging and expanding the availability of social support. Moreover, deeper reforms are needed to address inequalities between urban and rural areas in China.Background The supero-lateral medial forebrain bundle (slMFB) and the anterior thalamic radiation (ATR) play a core role in reward anticipation and motivational processes. In this study, the slMFB and the ATR were investigated in a group of depressed bipolar disorder (BD) and in healthy controls (HC) using tract length as a measure of fibre geometry and fractional anisotropy (FA) as a measure of white matter microstructure. We hypothesized reduced tract length and FA of the slMFB and the ATR in BD. We expect alterations to be driven by the melancholic subtype. Methods Nineteen depressed patients with BD and 19 HC matched for age and gender underwent diffusion-weighted magnetic resonance imaging (MRI) scans. https://www.selleckchem.com/products/sgc707.html Diffusion tensor imaging (DTI) based tractography was used to reconstruct bilateral slMFB and ATR. Mean tract length and FA were computed for the slMFB and the ATR. Mixed-model ANCOVAs and post-hoc ANCOVAs, controlling for age and intracranial volume, were used to compare tract length and FA of bilateral slMFB and ATR between HC and BD and between HC and subgroups with melancholic and non-melancholic symptoms.