Phenolic compounds are secondary metabolites involved in plant adaptation processes. The development of extraction procedures, quantification, and identification of this compounds in habanero pepper (Capsicum chinense) leaves can provide information about their accumulation and possible biological function. The main objective of this work was to study the effect of the UAE method and the polarity of different extraction solvents on the recovery of phenolic compounds from C. chinense leaves. Quantification of the total phenolic content (TPC), antioxidant activity (AA) by ABTS+ and DPPH radical inhibition methods, and the relation between the dielectric constant (ε) as polarity parameter of the solvents and TPC using Weibull and Gaussian distribution models was analyzed. The major phenolic compounds in C. chinense leaves extracts were identified and quantified by UPLC-PDA-ESI-MS/MS. The highest recovery of TPC (24.39 ± 2.41 mg GAE g-1 dry wt) was obtained using MeOH (50%) by UAE method. Correlations between TPC and AA of 0.89 and 0.91 were found for both radical inhibition methods (ABTS+ and DPPH). The Weibull and Gaussian models showed high regression values (0.93 to 0.95) suggesting that the highest phenolic compounds recovery is obtained using solvents with "ε" values between 35 and 52 by UAE. The major compounds were identified as N-caffeoyl putrescine, apigenin, luteolin and diosmetin derivatives. The models presented are proposed as a useful tool to predict the appropriate solvent composition for the extraction of phenolic compounds from C. chinense leaves by UAE based on the "ε" of the solvents for future metabolomic studies. The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a "master curve" of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period. The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.The actual speed behaviour when drivers approach a curve is very relevant to assess the road design and safety but is mostly overlooked in the scientific literature. Most research into curve driving behaviour is focussed at the behaviour inside the curve, although the speed selection is done before curve entry. The main objective of this research is to identify which freeway characteristics play a role in driving speed selection. High Frequency Floating Car Data, detailed reconstruction of the curves and their surroundings, as well as three dimensional sight distance analysis, were used to analyse individual speed profiles on 153 Dutch freeway curves. By defining the positions where the acceleration approaches 0 m/s2 before and after a curve starts, the positions when the driver started and stopped decelerating upon curve entry were defined. Further correlation and regression analysis of those positions revealed that the radius of the curve is indeed a main explaining variable, as well as the speed driven before deceleration starts. https://www.selleckchem.com/products/gsk2334470.html Sight distances and cross section characteristics play a further role in determining the position where deceleration starts. Deceleration ends at approximately 135 m after curve start, and the speed in a curve is also correlated with the deflection angle and length of a curve. Sight distances do not play a role in selecting the speed in a curve based on this research. Overall, the findings indicate a non-constant nature and variability of speed behaviour upon curve entry. This can be used for safer freeway curve design and to assess traffic safety based on actual speed behaviour.Work zones are established to provide a safe environment for all road users and road workers. However, based on the statistics, they can be considered as crash prone zones due to changes in the road alignments and the posted speed limits. In this driving simulator study, we aimed at investigating the safety impacts of a newly proposed system composed of graphical and animation-based variable message signs (VMSs) in the state of Qatar. The proposed VMS condition was compared with a control condition that was designed following the Qatar Work Zone Traffic Management Guide. A total of seventy subjects were invited to participate in the experiment voluntarily. Study results showed that in the VMS condition, drivers reduced their traveling speeds in advanced compared to the control condition. Drivers' traveling speed in the VMS condition was significantly reduced by 6.3 and 11.1 km/h on the leftmost and the second leftmost lanes, respectively. Next, the results uncovered that the proposed system motivated drivers to initiate early lane changing maneuvers, i.e., 150 m earlier than the control condition. Finally, the VMS condition was effective in stimulating drivers to keep larger headways with a merging vehicle. In sum, the proposed VMS system outperformed the control condition in terms of speed reduction, early merging, and higher headways between the through and the merging vehicle.