Asthma poses a threat to human health, and its pathogenesis is closely related to the neuroimmune system. Majie cataplasm can not only regulate the immune system but also the nervous system in asthma patients for its components. We speculate that Majie cataplasm may relieve asthmatic patients with sensitivity to hormone or not by regulating the body's neuroimmune system. Methods In this experiment, a mouse model of asthma was well established by ovalbumin. The lung function of animals was examined and pathological changes in the lung tissue were assessed by hematoxylin-eosin staining. Serum immunoglobulin E (IgE), calcitonin gene-related peptide (CGRP) and neurokinin A (NKA) were measured by ELISA. The location of CGRP, CD3 and neutrophil in lung tissue and their expressions were detected by immunofluorescence staining. In addition, contents of CGRP mRNA, Substance P (SP) mRNA, interleukin (IL)-17 mRNA and interleukin(IL)-13 mRNA were detected by quantitative polymerase chain reaction. Results Compared with the asthma model group, Majie cataplasm and dexamethasone can not only equivalently relieve airway hyperresponsiveness, but also make the content of serum IgE reduced. In addition, they can lower the content of serum CGRP and NKA after OVA stimulation, and this effect was more obvious for Majie cataplasm. Our results also showed that Majie Cataplasm and dexamethasone could inhibit the secretion of CGRP and the infiltration of T lymphocytes together with neutrophils in lung tissue and reduce expressions of CGRP mRNA, SP mRNA, IL-17 mRNA and IL-13 mRNA in lung tissue. Conclusion Majie cataplasm effectively relieves expressions of neuropeptides such as CGRP, reduces the infiltration of immune cells in lung tissue, regulates the body's neuroimmune system, and has a therapeutic potential for both Th2 asthma and neutrophilic asthma.Introduction Low birth weight (LBW) is an important general health indicator. The present study was conducted to evaluate the prevalence and risk factors of LBW in Iran. Method This meta-analysis was reported based on the PRISMA guidelines. All stages were independently performed by two authors. This review is registered with PROSPERO (CRD42020163446). We searched epidemiological studies at international databases of Scopus, Embase, Science Direct, PubMed/Medline, CINAHL, EBSCO, Cochrane Library, Web of Science, and Google Scholar search engine, as well as Iranian databases of SID, IranDoc, Iranian National Library, Barakat Knowledge Network System, RICST and Magiran using MeSH keywords without time limit until 2019. After selecting the studies, applying the inclusion and exclusion criteria, data extraction and qualitative assessment, the data were analyzed based on random effects model using Comprehensive Meta-Analysis Software version 2. P 2 (P less then 0.001), prematurity (P less then 0.001), history of LBW (P less then 0.001), multiple birth (P less then 0.001), abortion (P less then 0.001), vaginal bleeding (P less then 0.001), hypertension (P = 0.001) and preeclampsia (P less then 0.001). Conclusion The results of this meta-analysis showed that LBW is prevalent in Iran. This study can be a national database for LBW that would be of interest to Iranian health policy-makers and planners.In this present study, the impacts of magnetic field and thermal radiation on squeezing flow and heat transfer of third grade nanofluid between two disks embedded in a porous medium with temperature jump boundary conditions is analyzed using differential transformation method. The results of the approximate analytical solutions are verified using a fifth-order Runge-Kutta Fehlberg method (Cash-Karp Runge-Kutta) coupled with shooting method. From the analysis, the results of the two methods show excellent agreements. Also, the parametric studies using the approximate analytical solutions show that for a suction parameter greater than zero, the radial velocity of the lower disc increases while that of the upper disc decreases as a result of a corresponding increase in the viscosity of the fluid from the lower squeezing disc to the upper disc. For an increasing magnetic field parameter, the radial velocity of the lower disc decreases while that of the upper disc increases. As the third grade fluid parameter increases, there is a reduction in the fluid viscosity thereby increasing resistance between the fluid molecules. Also, it is found that as the radiation parameter increases, rate of heat transfer to the third grade fluid increases. There is a recorded decrease in the fluid temperature profile as the Prandtl number increases due to decrease in the thermal diffusivity of the third grade fluid. https://www.selleckchem.com/products/sw-100.html The agreement of the results of the present study and the experimental work shows the validation of the models used in this work to study the flow behaviour of the fluid. It is envisaged that the present work will increase the understanding of the flow behaviour of third grade nanofluid and heat transfer processes as evident in coal slurries, polymer solutions, textiles, ceramics, catalytic reactors, oil recovery applications etc.Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by John Cunningham Virus (JCV). We report four PML cases in immunocompromised patients, respectively treated with (1) Natalizumab, (2) Rituximab, (3) autologous stem-cell transplantation, and (4) Tacrolimus. All patients underwent neurological examination, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), JCV-DNA research on biological samples, and lymphocytes subpopulation study. All cases presented with motor, behavioural, and cognitive disorders. Visual, sensitive, and cerebellar deficits developed in three cases. MRI revealed widespread progressive demyelinating areas with active borders; three patients presented contrast enhancement. One patient developed inflammatory reconstitution syndrome (IRIS). At MRS, all cases presented decreased N-acetyl-aspartate (NAA) and three cases showed increased choline (Cho). In one patient, plasma and urine tested positive for JCV-DNA, while cerebrospinal fluid (CSF) analysis confirmed JCV in two patients.