(3) The optimized PTMD controls the development of structural plasticity reducing vulnerability. (4) There is a strong dependence of the optimum PTMD parameters on the dynamic soil properties of the building foundation. (5) The PTMD performance improves as its mass increases. The optimum frequency ratio decreases, and the damping ratio increases as the mass of the pendulum increases. The PTMD designed and optimized with the proposed methodology reduces vibrations, controls the development of plasticity, and protects the primary structure, particularly in low and medium-intensity earthquakes.The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.This study compared the thin-layer drying kinetics of hot-air methods, namely, convective oven drying (OVD), uncontrolled solar drying (UAD) and modified ventilation greenhouse solar drying (MVD). Additionally, the effects of these drying techniques on colour, rehydration characteristics and microstructure of Tommy Atkin mango slices were investigated. The experiments were conducted on mango slices of three different thicknesses 3 mm, 6 mm and 9 mm. The drying curves generated from the experimental data revealed that the rate of drying increased with thickness and that a thickness of 3 mm is optimal. It was discovered that increased drying rates resulted in a decrease in the drying time. When 3 mm slices were dried using OVD and MVD, the duration of the drying process was reduced by 85% and 80%, respectively, in comparison to the samples dried under UAD conditions. Lemon juice pre-drying treatment had no significant (p less then 0.05) effect on the drying rate or duration of the drying process. Non-linear regression analysis was used to optimise the drying coefficients by fitting the moisture ratio data to eleven suitable thin-layer models. The model parameters developed by Midilli et al. performed the best in terms of predicting the experimental moisture ratio (R2 = 0.9810-0.9981, χ 2 = 1.465 × 10-6-3.081 × 10-5 and RMSE = 0.0003-0.0004). Additionally, increasing the slice thickness to 6 mm and 9 mm prolonged the drying times, resulting in significant changes in sample quality, including the total colour (ΔE), rehydration and microstructure. In comparison to OVD- and MVD-dried samples, UAD-dried samples exhibited the greatest colour change and had the highest rehydration ratio values. https://www.selleckchem.com/products/BMS-777607.html Also, the surface of the UAD-dried samples developed a more porous structure with distinct cracks. Based on the results, MVD was determined to be a viable alternative method for drying 3 mm mango slices on a large scale.A new generalized class of distributions called the Lindley-Burr XII Power Series (LBXIIPS) distribution is proposed and explored. This new class of distributions contain some special cases such as Lindley-Burr XII Poisson (LBXIIP), Lindley-Burr XII Logarithmic (LBXIIL), Lindley-Burr XII Binomial (LBXIIB) and their sub-models among others. Some structural properties of the new distribution including moments, probability weighted moments, distribution of the order statistics and entropy are derived. Maximum likelihood estimation technique is used to estimate the model parameters. A simulation study to examine the bias and mean square error of the maximum likelihood estimators is presented and finally, an application to a real data set in order to illustrate the usefulness of the new distribution is given. Fear is a primary emotional reaction to the deadly coronavirus disease which might be an associated factor for developing depressive symptoms. This study aimed to assess the level and associated factors of fear and depression amid the COVID-19 pandemic among the adult population of Bangladesh. After providing informed consent, 1050 participants completed the cross-sectional online survey tool. Depressive symptoms and fear were assessed through the PHQ-9 and validated fear of COVID-19 scale (FCV-19S), respectively. Linear regression analysis was performed to predict potential factors of fear and depression. The study finds that females had higher scores for fear of COVID-19 scale (β1' = 1.81; 95% CI 1.15 to 2.47) and Patient Health Questionnaire (β2' = 1.92; 95% CI 0.95 to 2.88) than their male counterpart. Respondents considering the virus to be extremely dangerous had higher scores for FCV-19S (β1' = 1.55; 95% CI 0.66 to 2.44) and PHQ-9 (β2 = 1.59; 95% CI 0.25 to 2.92). Similarly, respondents considering themselves unsafe and very worried about the virus had increased scores for both FCV-19S and PHQ-9. On other hand, people those were reluctant to use masks (β1' = -1.58; 95% CI -3.12 to -0.04) or seek doctors' advice (β1' = -0.93; 95% CI -1.83 to -0.02) if COVID-19 symptoms appear, had comparatively lower scores for FCV-19S. Fear of COVID-19 and depression were found to be associated with some specific knowledge, attitude & preparedness towards COVID-19 which should be adequately addressed in public health strategies to prevent the virus. Fear of COVID-19 and depression were found to be associated with some specific knowledge, attitude & preparedness towards COVID-19 which should be adequately addressed in public health strategies to prevent the virus. A high percentage of the population in Latin America lives with intestinal parasitic infections, a neglected tropical disease frequently not treated. Intestinal parasitism is associated with other disorders, but information about the epidemiological situation in countries like Bolivia is scarce. Environmental conditions play a role in the prevalence of certain parasites. The main objective was to know the current situation of parasitic infections among children under 12years old from different geographical areas of Cochabamba - Bolivia. We analysed the laboratory reports of four second-line hospitals in different areas and the Tertiary Care Hospital. Results of stool examinations performed between 2011 and 2015 in children under 12years of age were collected. We gathered the results of 23,221 examinations. The 89% of children were less than five years old. Pathogenic parasites were found in 31%. and were the two most prevalent parasites in all areas. Helminths were 19% of positive samples and was the most prevalent.