In males, FT3 level was positively correlated with waist circumference (WC) and SMI and negatively correlated with EWF. Free thyroxine (FT4) level in both women and men was positively correlated with body fat mass (BFM) and left lower-limb muscle mass (LLLMM). Moreover, in males, FT4 level was correlated with more body composition parameters. In euthyroid T2DM patients, FT3 level was positively correlated with SMI and negatively correlated with EWF, while FT4 level was positively correlated with BFM and LLLMM. CONCLUSIONS Thyroid function can affect body composition in euthyroid T2DM patients. Thyroid function is more likely to affect the fat and muscle distribution of males than females.Despite considerable interest in the holistic recognition and treatment of human beings, many areas of health and its pathology remain overlooked in individual medical disciplines. These include circadian rhythms and wakefulness, including sleep and its disorders. Sleep is a basic human need, right next to it - breathing, eating, drinking, shelter, warmth and sex. Its biological function is associated with the main processes of regeneration, energy-saving and survival. It has a significant impact on the course of life functions, such as the development of nerve cells, learning mechanisms, memory, emotional regulation, cardiovascular function, metabolism and in the process of removing cellular toxins. Good sleep - in quantitative and qualitative terms, is a key element of good physical, mental and sexual health, and is also important for improving the overall quality of life. Despite the great interest in the right way of caring for health and well-being, knowledge about promoting health in the field of good sleep is still insufficient. There is a need to create an educational base for medical staff dealing with sleep dysfunctions and disorders, especially in patients affected by cancer. Often, oncology is referred to as "internal medicine with cancers", which mainly focuses on the diagnosis and treatment of cancer, and it would be worth paying attention to the aspect of supportive treatment and support for oncological patients by improving the patient's other life needs, including sleep. Oncologist's cooperation with specialists dealing with sleep disorders and circadian rhythms seems to be a necessary element of the holistic treatment of patients.SARS-CoV-2 (Severe Respiratory Syndrome Coronavirus-2), is a new strain of β-coronavirus. At the time of the current pandemic, pregnant women fear of infection by this pathogen and related consequences both for themselves and for their children. Adaptive changes occurring in the body of a pregnant woman can increase her susceptibility to infections, especially when it concerns the cardiopulmonary system. Clinical data relating to infection by this pathogen, referred to as Coronavirus Disease 2019 (COVID-19) in pregnant women are still limited. Most of the cases in which these data are available apply to the third trimester of pregnancy. This article provides an overview of a current knowledge and recommendations regarding the management of SARS-CoV-2 infection during pregnancy and its impact on the pregnancy outcome.Veillonella spp is part of the normal flora of the mouth, bowels and vagina, but in most of the studies the immunomodulatory properties of intestinal microbiota was described. https://www.selleckchem.com/products/kira6.html Despite of numerous studies on immunomodulatory activity of the microbiome's, most of them are focused on the intestinal microbiome. On the contrary, last finding of lung cancer patients shows higher level of Capnocytophaga and Veillonella, which may serve as potential biomarkers. Unfortunately, in local tumor microenvironment the competition for access to oxygen and nutrients within the microbiological context are not strictly described. In the case report such unique interaction with importance in clinical course of non small cell lung cancer (NSCLC) was described. Patient with NSCLC was admitted to surgical procedure. Unluckily, patients before therapy suffered brain trauma (metastases and meningitis were excluded). The oncologic intervention delayed patients has not receive neoadjuvant chemotherapy. Within near 2 months the infectitatistical coexistence of several bacteria and cancer our observation was evidence-based tumor specimen was microbiologically analysed. Our observation indicate significant role of commensal anaerobic bacteria in clinical history of cancer patient, opportunistic type of infectious process as well as therapeuthic prospect proliferative potential and anaerobic glycolysis of commensal Veillonella reduce access of cancer cells to nutrition's. It shed light on crucial role of innate immune response, acute phase reaction and neutrophils in immunotherapy outcome. Contrary to previous studies with statistical coexistence of several bacteria and cancer our observation was evidence-based tumor specimen was microbiologically analysed.A complex cardiac surgery may be associated with a number of complications. The occurrence of toxic epidermal necrolysis (TEN) in the postoperative period in a patient who has already experienced other complications contributes to the worsening of his prognosis. Despite the regression of necrotic skin lesions TEN can lead to tragic complications. A 48-year-old patient was admitted as scheduled to a cardiac surgery ward for a complex cardiac surgery. During the procedure, a mechanical aortic valve prosthesis, an ascending aorta prosthesis were implanted, and the left internal thoracic artery (LIMA) was grafted to the left anterior descending coronary artery (LAD). The intraoperative course was not complicated. In the postoperative period, some fluid was found in the left pleural cavity, which was decompressed. In the following days of the postoperative period an instability of the sternum and a serous-bloody discharge from the wound ocurred, these resulted in the reoperation and use of vacuum-assisted closure (VAC) therapy. Later, there were also haemorrhagic complications requiring surgical intervention and numerous transfusions of blood components. The patient was diagnosed with a very rare complication in the form of toxic epidermal necrolysis. Despite the therapy and regression of skin lesions an irreversible multi-organ failure developed in the patient which resulted in his death. Toxic epidermal necrolysis turned out to be a complication significantly contributing to the patient's death. Toxic epidermal necrolysis turned out to be a complication significantly contributing to the patient's death.