Oxygen supply failures are potentially life-threatening and are often associated with death or brain damage. Knowledge of how oxygen is supplied is essential for understanding how failures are caused and their management. Even though safety mechanisms exist to reduce the likelihood of a supply failure, events still occur. Simulation studies have identified knowledge and performance gaps in management of supply failures. A straightforward approach to immediate management of these critical events is provided.Anesthesiologists are uniquely positioned to facilitate emergent care of patients with sepsis in the perioperative setting. A subset of sepsis patients presents with surgical pathology. Emphasis is on timely intervention with source control, antibiotic therapy, and aggressive resuscitation. Ileus, aspiration, and cardiovascular collapse must be considered when inducing patients with sepsis. Dynamic fluid responsiveness may prove an effective tool in minimizing over-resuscitation. Assessment of circulatory failure and drug therapy involves an understanding of preload, afterload, and contractility. Timely, targeted resuscitation and early source control have persisted and remain fundamental to sepsis care.Management of the unanticipated difficult airway is one of the most relevant and challenging crisis management scenarios encountered in clinical anesthesia practice. Several guidelines and approaches have been developed to assist clinicians in navigating this high-acuity scenario. In the most serious cases, the clinician may encounter a failed airway that results from failure to ventilate an anesthetized patient via facemask or supraglottic airway or intubate the patient with an endotracheal tube. This dreaded cannot intubate, cannot oxygenate situation necessitates emergency invasive access. This article reviews the incidence, management, and complications of the failed airway and training issues related to its management.Cardiac arrest in the operating room and in the immediate postoperative period is a potentially catastrophic event that is almost always witnessed and is frequently anticipated. Perioperative crises and perioperative cardiac arrest, although often catastrophic, are frequently managed in a timely and directed manner because practitioners have a deep knowledge of the patient's medical condition and details of recent procedures. It is hoped that the approaches described here, along with approaches for the rapid identification and management of specific high-stakes clinical scenarios, will help anesthesiologists continue to improve patient outcomes.Peripartum hemorrhage is a leading cause of maternal morbidity and mortality. Anesthesiologists must be familiar with conditions associated with hemorrhage that are unique to labor and delivery and not seen elsewhere in their practice. Regardless of etiology, early recognition and timely treatment of obstetric hemorrhage is necessary to prevent significant blood loss. Massive transfusion protocols are crucial to successful resuscitation, and providers should also consider use of cell salvage, uterine artery embolization, and anti-fibrinolytics. Because more than half the deaths due to hemorrhage are preventable, multidisciplinary care bundles should be used on every labor and delivery unit.There are many forms of mass casualty events, including mass trauma, exposure to radiation and chemical agents, biological exposure (pandemics and bioterrorism), or a combination of insults. The underlying theme is that the number and severity of patients outstrip the resources available. These events are more common than thought. Planning and preparation allow institutions to better respond to the patient surge and thus mitigate the consequences-ultimately saving lives and reducing morbidity.Debriefing after perioperative crises (eg, cardiac arrest, massive hemorrhage) is a well-described practice that can provide benefits to individuals, teams, and health systems. https://www.selleckchem.com/products/af353.html Debriefing has also been embraced by high-stakes industries outside of health care. Yet, in studies of actual clinical practice, there are many critical events that do not get debriefed. This article explores the gap that exists between principle and reality and the factors and strategies to offer opportunities to reflect on actual critical events, when indicated, across the increasing scope of environments where anesthesia care is provided.Critical events are rare and stressful. These properties make reliance on memory for clinical management highly susceptible to failure. In the past 10 to 20 years, health care has begun to accept the experience of aviation and other high-reliability organizations in addressing failure to rescue from these events through a combination of practice through simulation and the introduction of cognitive aids, known as checklists or emergency manuals. Cognitive aids have a persuasive body of evidence from simulation studies to establish their value in improving clinician performance. However, their introduction to practice is more complex than distribution of the tools.Postoperative complications, which occur in approximately 23% of surgeries, are a major source of patient mortality. Some of these deaths may be preventable. This article explores factors and contexts during the intraoperative period, in the postanesthesia care unit, perioperatively, and after discharge that may represent opportunities to intervene and prevent mortality after a potentially treatable complication. Tools to improve the identification and response to life-threatening complications in these unique care settings are discussed.Simulation-based education improves health care professionals' performance in managing critical events. Limitations to widespread uptake of high-fidelity simulation include barriers related to training, technology, and time. Alternatives to high-fidelity simulation that overcome these barriers include in situ simulation, classroom-based simulation, telesimulation, observed simulation, screen-based simulation, and game-based simulation. Some settings have limited access to onsite expert facilitation to design, implement, and guide participants through simulation-based education. Alternatives to onsite expert debriefing in these settings include teledebriefing, scripted debriefing, and within-group debriefing. A combination of these alternatives promotes successful implementation and maintenance of simulation-based education for managing critical health care events.