The conductivity data recorded varied from -20 mS/m to about 440 mS/m at a maximum depth of about 375 m. On the other hand, the resistivity data recorded varied from 0 Oh-m to about 1000 Oh-m. The information derived from the data are intended for potential abstraction by the Malaysian Groundwater Management Board; the Department of Mineral and Geoscience; Department of Irrigation and Drainage; the Pahang State Water Board, and the Department of Agriculture. © 2020 The Author(s).This paper presents additional data on the leaf structural, physiological and nutritional characteristics of three species (Maytenus obtusifolia, Manilkara subsericea e Inga laurina), co-occurring in restinga and semideciduous seasonal forest (forest). The data of the leaf structural, physiological and nutritional characteristics were obtained from the three species to identify possible adaptive strategies that could explain the co-occurrence of these species in the restinga and forest. In addition, this data can help identify key functional traits in the plant community of restinga and forests that can be employed in the reestablishment of ecological and edaphic processes in these ecosystems. This work presents data complementary to the published article "Acclimatization capacity of leaf traits of species co-occurring in restinga and seasonal semideciduous forest ecosystems" [1]. © 2020 The Author(s).Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel is a nonselective cation channel permeable to calcium and is activated by various physiological and pharmacological stimuli. TRPV1 and TRPV4, in particular, have important roles in intracellular Ca2+ signaling and extracellular calcium homeostasis in bone cells. TRPV1 and TRPV4 separately mediate osteoclast and osteoblast differentiation, and deficiency in any of these channels leads to increased bone mass. However, it remains unknown whether bone mass increases in the absence of both TRPV1 and TRPV4. In this study, we used TRPV1 and TRPV4 double knockout (DKO) **** to evaluate their bone mass in vivo, and osteoclast and osteoblast differentiation in vitro. Our results showed that DKO **** and wild type (WT) **** had no significant difference in body weight and femur length. However, the results of dual-energy X-ray absorption, microcomputed tomography, and bone histomorphometry clearly showed that DKO The Authors.Denosumab discontinuation has been associated with increased risk of rebound-associated multiple vertebral fractures. We report the cases of three patients, two females and one male, who had manifested rebound-associated vertebral fractures after denosumab discontinuation and sustained new vertebral fractures a few months later. Two of the patients had been previously treated with bisphosphonates. Patients discontinued denosumab after 2 to 8 years of treatment. One of the female patients was receiving prednisolone 7.5 mg daily for an unspecified connective tissue disorder and the male patient methylprednisolone 8 mg daily for dermatomyositis. We hypothesize that rebound-associated multiple vertebral fractures after denosumab discontinuation may occur, at least in some cases, sequentially instead of simultaneously. Our cases further underpin the need for prompt initiation of potent antiresorptives in patients who sustained rebound-associated vertebral fractures, in order to prevent not only bone loss but also a second round of fractures. © 2020 Published by Elsevier Inc.The internal mammary vessels are commonly used for anastomosis in breast reconstruction. https://www.selleckchem.com/products/3-deazaneplanocin-a-dznep.html The anatomy when using the 2nd ICS has been shown to be predictable and hence preferentially used by the senior author. We present an unusual case of internal mammary vein bifurcation and immediate confluence forming a 'venous circle'. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.We report a rare case of a subcutaneous mass on the finger, which was suspected to be a soft tissue tumour and was reconstructed using a digital artery flap after excision biopsy. Tophaceous gout was pathologically diagnosed. The patient had no prior gouty attacks, making the preoperative diagnosis difficult. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.https//onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312941-sup-v001.htm. © 2020 International Parkinson and Movement Disorder Society.https//onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312943-sup-v001.htm. © 2020 International Parkinson and Movement Disorder Society.Background X-linked dystonia parkinsonism (XDP) is a rare disorder characterized by adult-onset, progressive dystonia that, over time, is combined with or replaced by features of parkinsonism. Gait impairment is common. Methods Case series of 4 XDP patients with a unique gait disorder. Results The patients displayed a characteristic gait disorder with combined dystonic and parkinsonian gait features, with phasic knee bending. Of these patients, all had parkinsonism and three-quarters had prominent dystonic features, but 1 had predominant parkinsonism and subtle dystonic features. Conclusion Although XDP is a classic form of dystonia parkinsonism, some cases can mimic idiopathic Parkinson's disease. We describe a gait disorder which appears unique to XDP, involving phasic dystonic knee bending superimposed on parkinsonian shuffling, and may help clinically differentiate one of our parkinsonian-predominant patients from more-common forms of parkinsonism. The gait is distinct from other complex dystonic disorders with gait involvement. © 2020 International Parkinson and Movement Disorder Society.Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease without approved therapies, and therapeutics are often tried off-label in the hope of slowing disease progression. Results from these experiences are seldom shared, which limits evidence-based knowledge to guide future treatment decisions. Objectives To describe an open-label experience, including safety/tolerability, and longitudinal changes in biomarkers of disease progression in PSP-Richardson's syndrome (PSP-RS) patients treated with either salsalate or young plasma and compare to natural history data from previous multicenter studies. Methods For 6 months, 10 PSP-RS patients received daily salsalate 2,250 mg, and 5 patients received monthly infusions of four units of young plasma. Every 3 months, clinical severity was assessed with the Progressive Supranuclear Palsy Rating Scale (PSPRS), and MRI was obtained for volumetric measurement of midbrain. A range of exploratory biomarkers, including cerebrospinal fluid levels of neurofilament light chain, were collected at baseline and 6 months.
The conductivity data recorded varied from -20 mS/m to about 440 mS/m at a maximum depth of about 375 m. On the other hand, the resistivity data recorded varied from 0 Oh-m to about 1000 Oh-m. The information derived from the data are intended for potential abstraction by the Malaysian Groundwater Management Board; the Department of Mineral and Geoscience; Department of Irrigation and Drainage; the Pahang State Water Board, and the Department of Agriculture. © 2020 The Author(s).This paper presents additional data on the leaf structural, physiological and nutritional characteristics of three species (Maytenus obtusifolia, Manilkara subsericea e Inga laurina), co-occurring in restinga and semideciduous seasonal forest (forest). The data of the leaf structural, physiological and nutritional characteristics were obtained from the three species to identify possible adaptive strategies that could explain the co-occurrence of these species in the restinga and forest. In addition, this data can help identify key functional traits in the plant community of restinga and forests that can be employed in the reestablishment of ecological and edaphic processes in these ecosystems. This work presents data complementary to the published article "Acclimatization capacity of leaf traits of species co-occurring in restinga and seasonal semideciduous forest ecosystems" [1]. © 2020 The Author(s).Calcium balance is important in bone homeostasis. The transient receptor potential vanilloid (TRPV) channel is a nonselective cation channel permeable to calcium and is activated by various physiological and pharmacological stimuli. TRPV1 and TRPV4, in particular, have important roles in intracellular Ca2+ signaling and extracellular calcium homeostasis in bone cells. TRPV1 and TRPV4 separately mediate osteoclast and osteoblast differentiation, and deficiency in any of these channels leads to increased bone mass. However, it remains unknown whether bone mass increases in the absence of both TRPV1 and TRPV4. In this study, we used TRPV1 and TRPV4 double knockout (DKO) mice to evaluate their bone mass in vivo, and osteoclast and osteoblast differentiation in vitro. Our results showed that DKO mice and wild type (WT) mice had no significant difference in body weight and femur length. However, the results of dual-energy X-ray absorption, microcomputed tomography, and bone histomorphometry clearly showed that DKO The Authors.Denosumab discontinuation has been associated with increased risk of rebound-associated multiple vertebral fractures. We report the cases of three patients, two females and one male, who had manifested rebound-associated vertebral fractures after denosumab discontinuation and sustained new vertebral fractures a few months later. Two of the patients had been previously treated with bisphosphonates. Patients discontinued denosumab after 2 to 8 years of treatment. One of the female patients was receiving prednisolone 7.5 mg daily for an unspecified connective tissue disorder and the male patient methylprednisolone 8 mg daily for dermatomyositis. We hypothesize that rebound-associated multiple vertebral fractures after denosumab discontinuation may occur, at least in some cases, sequentially instead of simultaneously. Our cases further underpin the need for prompt initiation of potent antiresorptives in patients who sustained rebound-associated vertebral fractures, in order to prevent not only bone loss but also a second round of fractures. © 2020 Published by Elsevier Inc.The internal mammary vessels are commonly used for anastomosis in breast reconstruction. https://www.selleckchem.com/products/3-deazaneplanocin-a-dznep.html The anatomy when using the 2nd ICS has been shown to be predictable and hence preferentially used by the senior author. We present an unusual case of internal mammary vein bifurcation and immediate confluence forming a 'venous circle'. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.We report a rare case of a subcutaneous mass on the finger, which was suspected to be a soft tissue tumour and was reconstructed using a digital artery flap after excision biopsy. Tophaceous gout was pathologically diagnosed. The patient had no prior gouty attacks, making the preoperative diagnosis difficult. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.https//onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312941-sup-v001.htm. © 2020 International Parkinson and Movement Disorder Society.https//onlinelibrary.wiley.com/page/journal/23301619/homepage/mdc312943-sup-v001.htm. © 2020 International Parkinson and Movement Disorder Society.Background X-linked dystonia parkinsonism (XDP) is a rare disorder characterized by adult-onset, progressive dystonia that, over time, is combined with or replaced by features of parkinsonism. Gait impairment is common. Methods Case series of 4 XDP patients with a unique gait disorder. Results The patients displayed a characteristic gait disorder with combined dystonic and parkinsonian gait features, with phasic knee bending. Of these patients, all had parkinsonism and three-quarters had prominent dystonic features, but 1 had predominant parkinsonism and subtle dystonic features. Conclusion Although XDP is a classic form of dystonia parkinsonism, some cases can mimic idiopathic Parkinson's disease. We describe a gait disorder which appears unique to XDP, involving phasic dystonic knee bending superimposed on parkinsonian shuffling, and may help clinically differentiate one of our parkinsonian-predominant patients from more-common forms of parkinsonism. The gait is distinct from other complex dystonic disorders with gait involvement. © 2020 International Parkinson and Movement Disorder Society.Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease without approved therapies, and therapeutics are often tried off-label in the hope of slowing disease progression. Results from these experiences are seldom shared, which limits evidence-based knowledge to guide future treatment decisions. Objectives To describe an open-label experience, including safety/tolerability, and longitudinal changes in biomarkers of disease progression in PSP-Richardson's syndrome (PSP-RS) patients treated with either salsalate or young plasma and compare to natural history data from previous multicenter studies. Methods For 6 months, 10 PSP-RS patients received daily salsalate 2,250 mg, and 5 patients received monthly infusions of four units of young plasma. Every 3 months, clinical severity was assessed with the Progressive Supranuclear Palsy Rating Scale (PSPRS), and MRI was obtained for volumetric measurement of midbrain. A range of exploratory biomarkers, including cerebrospinal fluid levels of neurofilament light chain, were collected at baseline and 6 months.
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