4% in 2016 to 25.4% in 2019. The greatest increases were seen in NS (4.4% to 16.2%), LS (13.7% to 23.1%), and HA (55.8% to 61.9%). For several procedure types, there was an initial increase then either a leveling off or a decline in AF use OB initially increased from 6.2% to 10.8% in 2018, whereas GN (9.4% to 7.2%) and VA surgery declined slightly (9.9% to 5.7%). When comparing patients who did not receive AF with those who did, there were similar volumes of ICS available for return in all groups, except for LS, GN, and VA, where lower volumes were seen in the No-AF groups. The use of AF has increased each year over the 4-year period in most of the surgical categories, but several have declined. There may be a beneficial effect of AF with lower ICS volumes available for return in a few groups.There has been a rapid adoption of the use of del Nido cardioplegia (DC) among adults undergoing cardiac surgery. We leveraged a multicenter database to evaluate differences over time in the choice and impact of cardioplegia type (DC vs. blood) among patients undergoing cardiac surgery. We evaluated 26,373 patients undergoing non-emergent coronary artery bypass and/or valve surgery between 2014-2015 (early period) and 2017-2018 (late period) at 31 centers. DC was compared with blood-based cardioplegia (BC 11, 21, 41, 81, and variable ratio). We evaluated whether treatment choice differed across prespecified patient characteristics, procedure type, and perfusion practices by time period. We evaluated increased DC use with clinical outcomes (major morbidity and mortality, prolonged intubation, and renal failure), after adjusting for baseline characteristics, procedure type, center, and year. DC use increased from 19.6% in 2014-2015 to 41.5% in 2017-2018, p .05). In this large multicenter experience, DC use increased over time and was associated with reduced bypass and ischemic time absent any significant differences in adjusted outcomes.Cardiopulmonary bypass (CPB) is a highly technical clinical discipline with a recognized variability in practice. Professional standards and guidelines documents help direct clinical practice and reduce variability, but these guidelines are necessarily vague and fall short of providing specific objective recommendations of clinical practice metrics. If clinical practice metrics were known, they would be informative when writing departmental policy manuals, structuring quality improvement initiatives, describing product R&D specifications, and designing educational assessment rubrics. Therefore, to address this gap, we conducted a national survey of clinical practice with the purpose of producing a benchmark of the typical variability of specific technical parameters that are commonly managed during adult CPB procedures. A pool of expert clinical perfusionists collaborated to compile a data set of normal ranges for 41 individual physiologic and technical parameters (pressures, flows, saturation, times, solutiorameters that are managed during adult CPB. This information may be incorporated into guiding documents to support the work of clinicians, researchers, and educators.In 2011 a thermally anomalous region was discovered on Mimas, Saturn's innermost major icy satellite (Howett et al., 2011). The anomalous region is a lens-like shape located at low latitudes on Mimas' leading hemisphere. It manifests as a region with warmer nighttime temperatures, and cooler daytime ones than its surroundings. The thermally anomalous region is spatially correlated with a darkening in Mimas' IR/UV surface color (Schenk et al. 2011) and the region preferentially bombarded by high-energy electrons (Paranicas et al., 2012, 2014; Nordheim et al., 2017). We use data from Cassini's Composite Infrared Spectrometer (CIRS) to map Mimas' surface temperatures and its thermophysical properties. This provides a dramatic improvement on the work in Howett et al. (2011), where the values were determined at only two regions on Mimas (one inside, and another outside of the anomalous region). We use all spatially-resolved scans made by CIRS' focal plane 3 (FP3, 600 to 1100 cm-1) of Mimas' surface, which are larg same when their uncertainties are considered. These thermal inertia and albedo values determined here are consistent with those found by Howett et al. (2011), who determined the thermal inertia inside the anomaly to be 66±23 J m-2 K-1 s-1/2 and less then 16 J m-2 K-1 s-1/2 outside, with albedos that varied from 0.49 to 0.70.The burgeoning financial technology scene in Singapore has seen the emergence of robo-advisors, which aim to disrupt traditional financial advisories by using algorithms to automate client advising and investment recommendations. Using an ecologies concept to explore how lay investors are articulated into global financial networks through robo advisors, this paper contributes to studies on the "financialization of everyday life". It argues that investors are rendered passive by the disciplinary tools of algorithms, contemporary finance theories and elements of robo-advisor platforms that feed into these sociotechnological assemblages. The state's role in embedding citizen investors in these human-machine relationships is considered. The fragmented landscape of free, nonprofessional online financial advice and the opaque qualities of investing algorithms make investor subject formation incomplete and uncertain, especially when markets are highly volatile. This paper explores how both financial inclusion and exclusion operate simultaneously in robo-advisors and argues that robo-advisors may weaken efforts to promote financial literacy and education.In the wake of the COVID-19 pandemic, philanthropy has been quick to react to the call for help from Governments and International Organisations. And yet, despite the overwhelming response, increasing attention has been brought to the intricate ways in which philanthropists and billionaires have been asserting their presence through their actions and influence in different spheres of power. In this commentary, I challenge the idea that philanthropy can be the solution to all of our problems, and highlight some of the problematic issues that emerge when philanthropy is put at the forefront of the discussion. https://www.selleckchem.com/products/a2ti-1.html Also, I point out to other elements that have been left out, including the wave of collective solidarity that has been channelled through mutual aid groups and organisations.