BACKGROUND The use of mobile social media enables individuals to learn about others' lives, which may lead to upward social comparison. Evidence has shown that upward social comparison on mobile social media can have negative effect for individuals' mental health, such as a higher risk of depression. Previous studies on this issue have mainly focused on adolescents and college students, but less on married adults' well-being. Moreover, mechanisms underlying this association have not been well-documented. METHODS A total of 514 Chinese married adults (62% female) were recruited from 26 regions in China. They completed measures of upward social comparison on mobile social media, envy, marriage quality and depression. RESULTS The results showed a positive association between upward social comparison on mobile social media and depression, which was completely mediated by envy. The direct effect of upward social comparison on depression, and the relation between upward social comparison and envy, were both moderated by marital quality. More specifically that upward social comparison on mobile social media was more strongly associated with depression and envy in adults with lower marital quality. LIMITATIONS This study only focused on the interpersonal factor (i.e., marriage quality) as a moderating variable, not investigating the potential moderating roles of personality factors and other interpersonal factors. In addition, the cross-sectional in design could not examine the causal relationships among the variables. CONCLUSIONS High marriage quality can protect married adults from the adverse effects of upward social comparison on mobile social media. This paper investigates the mental health promotion and protection (MHPP) model of reducing depression. Data are from the Clergy Health Initiative Longitudinal Survey of United Methodist ministers in North Carolina that included the Mental Health Continuum Short Form (MHC-SF) for positive mental health and the Patient Health Questionnaire (PHQ-9) for depression in 2014 and 2016 (N = 955). The promotion hypothesis predicts reduced risk of depression in 2016 among clergy whose mental health increased to flourishing and the increased risk of depression in 2016 for clergy who stayed not flourishing. The protection hypothesis predicts increased risk of depression in 2016 for clergy who were flourishing in 2014 but went down to 'not flourishing' in 2016. The reference group is clergy who stayed flourishing. We used modified Poisson regression models for binary outcomes to estimate Prevalence Ratios (PR) and to estimate Incidence Rate Ratios (IRR) of depression in 2016 associated with changes in mental health status. Results support both hypotheses. Compared to clergy who stayed flourishing, clergy who improved to flourishing were as likely, while clergy who stayed not flourishing were nearly seven times more likely, to have depression in 2016. Clergy who declined to not flourishing were six times more likely to have depression in 2016 compared to those who stayed flourishing. Similar patterns were observed when the sample was restricted to clergy without depression in 2014. These findings suggest focusing on MHPP as a complementary approach to treatment to reduce the incidence, prevalence and burden of depression. BACKGROUND Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids might play a role in the pathogenesis of major psychiatric disorders. Here we studied whether expression of sEH protein is altered in the postmortem samples (parietal cortex, and liver) from patients with major psychiatric disorders. https://www.selleckchem.com/products/cfi-400945.html METHODS Protein expression of sEH in the parietal cortex and liver from control, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) groups was measured. RESULTS Levels of sEH in the parietal cortex and liver from MDD, BD, and SZ groups were significantly higher than the control group. Interestingly, there was a positive correlation between sEH protein in the parietal cortex and sEH protein the liver in all groups. LIMITATIONS The small number in each group may limit our interpretation. CONCLUSIONS This study shows that the increased expression of sEH in the brain and liver might play a role in the pathogenesis of major psychiatric disorders, suggesting a role of brain - liver axis in major psychiatric disorders. BACKGROUND Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages. Here, we examine whether genetic variants in the NET gene are associated, in an age-specific manner, with increased risk of generalized anxiety disorder (GAD), one of the most disabling anxiety disorders. METHODS Three common single-nucleotide polymorphisms (SNPs) in the promoter (rs168924 A/G; rs2242446 T/C) and 5'-untranslated region (5'-UTR) (rs2397771 G/C) of the NET gene were genotyped in 2,317 Han-Chinese participants (791 GAD patients and 1,526 controls; age 20-65). Potential confounding factors, such as gender, stress levels and psychiatric comorbidities, were included as covariates. RESULTS An interaction between age and NET genotypes and haplotypes was found for the risk of GAD. In the younger participants, rs168924 minor allele G homozygotes had the lowest incidence of GAD; however, older subjects displayed an inverse pattern, with homozygous G/G carriers presenting the highest prevalence of GAD. Additionally, younger individuals carrying 2 copies of the GGT haplotype composed of rs2397771-rs168924-rs2242446 had the lowest rate of GAD. However, those with 2 copies of the same haplotype exhibited the highest risk of GAD in the older groups. LIMITATIONS Only 3 common SNPs in the promoter and 5'-UTR of the NET gene were analyzed. CONCLUSIONS Our findings are the first to demonstrate that potentially functional SNPs in the NET promoter and 5'-UTR are associated with an increased risk of GAD, and that such associations are determined in an age-specific way. V.BACKGROUND It has been demonstrated that a reduction in the amount of high-frequency cardiopulmonary coupling (CPC) is indicative of unstable sleep in unmedicated patients with major depressive disorder (MDD). Considering the close relationship between sleep quality and memory consolidation, this study sought to investigate the potential of high-frequency CPC as a novel biomarker for objective evaluation of memory impairment in MDD. METHODS A total of 64 depressed patients and 35 healthy controls were included in this cross-sectional study. High-frequency coupling (HFC) was assessed by electrocardiogram-based CPC analysis using a portable sleep-respiration monitor during sleep for one night. The next day, subjects completed the cognition assessment with the Assessment of Neuropsychological Status (RBANS). The 17-Item Hamilton Depression Rating Scale (HAMD17) and the Hamilton Rating Scales for Anxiety (HAMA) were used to evaluate the severity of depression and anxiety in each patient, respectively. RESULTS There was no significant difference in the proportion of HFC between depressed patients and healthy controls.