This study aimed to comparatively evaluate the psychological well-being and health-related quality of life of subjects having either a convex or concave profile and abnormal overjet, with subjects having a straight profile and normal overjet. In this study, 163 children and their parents who applied to the Faculty of Dentistry were classified into 3 groups Group 1 convex profile, Class II molar relationship, and increased overjet (n=62; 28 boys and 34 girls; mean age 11.6 years); Group 2 concave profile, Class III molar relationship, and negative overjet (n=55; 32 boys and 23 girls; mean age 11.2 years); and Group 3 straight profile, Class I molar relationship without crowding, and normal overjet (n=46; 24 boys and 22 girls; mean age 11.0 years). The severity of malocclusion was evaluated using the Index of Orthodontic Treatment Need (IOTN). Self-concept, depression, and state-trait anxiety were evaluated to determine the psychological well-being of the children. No differences were found among the groups with respect to self-concept, depression levels, state-trait anxiety levels, and quality of life scores. No correlation was found between the IOTN scores and psychological well-being. Abnormalities in the facial profile and negative or increased overjet have no influence on children's psychological well-being. Abnormalities in the facial profile and negative or increased overjet have no influence on children's psychological well-being. In our study, it was aimed to determine whether there were differences in genial tubercle dimensions depending on age and gender. In this study, 220 cone beam computed tomography (CBCT) images of patients (110 female and 110 male) between the ages of 20-80 years were obtained from the archive of İzmir Katip Çelebi University Faculty of Dentistry. All patients were divided into decade groups according to their age, and each decade group was divided into two subgroups according to gender. The genial tubercle was defined radiologically using axial, coronal and sagittal sections as well as 3D reconstruction image with NNT software program. https://www.selleckchem.com/products/ms-275.html Sagittal, vertical and horizontal dimensions of the genial tubercle were measured and statistically analyzed. There was a weak negative correlation between age groups and vertical values (r=-0.142; p=0.036) whereas the correlation coefficients between age groups and sagittal and horizontal values were not statistically significant (r=-0.043; p=0.530 and r=-0.039; p=0.563). There was a strong positive correlation between vertical and sagittal values in men (r=0.705, p<0.001) and women (r=0.714, p<0.001) in the whole group. There was a weak positive correlation between horizontal and sagittal, horizontal and vertical values in men (r=0.362, p<0.001; r=0.231, p<0.001) and women (r=0.304, p<0.001; r=0.257, p=0.007) in the whole group. The vertical and horizontal dimensions of genial tubercle of men were higher than that of women. As the age of the patients increased, a decrease in the vertical values of the genial tubercle was observed. The vertical and horizontal dimensions of genial tubercle of men were higher than that of women. As the age of the patients increased, a decrease in the vertical values of the genial tubercle was observed. This study aimed to evaluate the relationship between the components of the objective grading system developed by the American Board of Orthodontics (ABO) and smile esthetics in Class I extraction vs non-extraction cases. A total of 40 extraoral smile images of orthodontically treated (20 extraction and 20 non-extraction) cases in the age group of 13-30 years and Class I skeletal malocclusion with an average mandibular plane angle were selected. Smile images were rated only by the orthodontist, and this panel included 12 members. Scoring of post-treatment dental casts and panoramic radiographs of each patient was performed by 1 investigator per the guidelines of the ABO grading system. The Pearson correlation coefficient and logistic regression analysis were used to ascertain whether the scores of the ABO grading system could foretell whether a smile would be "attractive" or "unattractive." The correlation between all the criteria of the ABO grading system and attractiveness of the smile was extremely weak. The r values ranged from -0.53 to 0.37 for extraction cases and -0.63 to 0.003 for non-extraction cases (p>0.05). Neither individual parameters nor total scores of the ABO grading system could predict whether the smile was attractive or unattractive in either group. No correlation was found between post-treatment ABO grading and smile esthetics in patients with extraction or non-extraction. Hence, this study recommends that ancillary soft tissue variables have to be incorporated into the grading system to evaluate a smile. No correlation was found between post-treatment ABO grading and smile esthetics in patients with extraction or non-extraction. Hence, this study recommends that ancillary soft tissue variables have to be incorporated into the grading system to evaluate a smile. This study aimed to evaluate the relationship between the calcification stages of permanent maxillary and mandibular canines and second premolars and skeletal maturity in both sexes. This study included 138 patients (82 females, 56 males) who were treated in the Department of Orthodontics, Altınbaş University. The mean age of the patients was 12.31±1.76 years, ranging from 7.8 years to 15.8 years. Dental maturity stages of canines and second premolars were evaluated according to the Demirjian index on digital panoramic radiograph. The skeletal maturation stage was determined using the cervical vertebral maturation (CVM) index. The Pearson correlation analysis was performed to assess the association among CVM stages and calcification stages of canines, second premolars, sex, and chronological ages. A statistically significant correlation was found between CVM and the calcification stages of the canines and second premolars (p<0.05). The calcification stages of the canines and second premolars had the highest distribution of Stage F and Stage G at CVM2 (p<0.01). For the canines and second premolars, Stage H corresponded to CVM3 in female patients and a high percentage of Stage G corresponded to CVM3 in the male group. A significant correlation was found between the calcification stages of maxillary and mandibular canines, second premolars, and skeletal maturity in both sexes. It was observed that calcification stages and cervical maturations were advanced in female subjects compared with male subjects. A significant correlation was found between the calcification stages of maxillary and mandibular canines, second premolars, and skeletal maturity in both sexes. It was observed that calcification stages and cervical maturations were advanced in female subjects compared with male subjects.