d the accumulation of pleural effusion. In resistant forms of tuberculosis, the immune response in the form of the activity of the proteolytic system, which is lower than in sensitive forms, can be explained by the exhaustion of the immune system under the influence of aggressive tuberculosis. The above can be associated with both the weakening of the patient's body and the aggressiveness of the pathogen. The aim To define the level of pro- and anti-inflammatory IL-1β, IL-10 in the oral fluid of children with chronic gastroduodenitis, depending on the level of IkBα expression. Materials and methods Studiing the oral fluid and scraping of the gums of 50 children 6-12 years old was carried out to determine the level of IL-1β, IL-10 and IkBα. The children were divided into 3 groups. Group 1 - 10 children with healthy periodontium and without somatic diseases. 2nd group - 20 somatically healthy children with chronic catarrhal gingivitis. The third group (20 children) of children with gastroduodenitis and chronic catarrhal gingivitis. The determination of the mRNA expression of the IkBα geneand the level of IL-10 and IL-1β in the oral fluid was carried out by real-time PCR. Results We determined that the level of pro-inflammatory IL-1β in the oral fluid of primary school children had different levels in accordance with the state of dental and somatic health. It was the lowest in somatically healthy children wry response associated with chronic catarrhal gingivitis and with chronic gastroduodenitis. The aim To obtain the first estimates data on the occurrence of antibiotic-resistant bacteria in a wide range of fresh vegetables available in the Kyiv city markets. Materials and methods We performed a multicenter study. Fresh vegetables samples were collected of the six different commodity groups from eleven of retail stores locatedin Kyiv, Ukraine. Samples were tested for up to eight bacteria of concern. The susceptibility to antibiotics was determined by disk diffusion method according to the European Committee on Antimicrobial Susceptibility Testing. Results The antibiotic-resistant bacteria contamination in the fresh vegetables was 24.3%. The contamination among organic produce was significantly higher than in conventionally products. Contamination was found to be higher in leafy vegetables. The predominant contaminated bacteria were Escherichia coli, Enterobacter spp. And Enterococcus faecalis, followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, E. faecium, Staphylococcus aureus and Acinetns to consumers. The aim To study the relationship between zonulin level and PNFI (pediatric non-alcoholic fatty liver disease fibrosis index) in obese adolescents. Material and methods A total of fifty-nine obese subjects aged 12-17 years and thirteen healthy subjects were included in the study. Clinical, biochemical parameters, including serum zonulin, were examined and abdominal ultrasound examination was performed. https://www.selleckchem.com/products/mln-4924.html For the assessment of liver fibrosis PNFI was calculated. Results According to ultrasound examination 71,2% of obese adolescents had non-alcoholic fatty liver disease (NAFLD). Calculation of PNFI showed that 25,4% of obese subjects had fibrotic processes in the liver. Obese adolescents had significantly higher zonulin levels compared to normal weight peers - 91,8±3,1 vs 15,9±5,1 respectively (р<0,01). A significant positive correlation was established between zonulin levels and such parameters as body mass index, waist circumference / height ratio, triglycerides, very low-density lipoprotein cholesterol, insulin, homeostasis model assessment of insulin resistance, PNFI (p<0,05). Conclusions The level of zonulin increases with an increase of the index for evaluating liver fibrosis (PNFI) in obese adolescents. This may indicate the effect of the state of the intestinal barrier on the development and progression of obesity-related liver pathology, namely NAFLD, in obese adolescents. Conclusions The level of zonulin increases with an increase of the index for evaluating liver fibrosis (PNFI) in obese adolescents. This may indicate the effect of the state of the intestinal barrier on the development and progression of obesity-related liver pathology, namely NAFLD, in obese adolescents. The aim To investigate the effectiveness of usage of the free radical scavenger Edaravone in the therapy of women with AIS. Materials and methods A prospective study was conducted of 48 women with AIS, divided into two groups. Patients in the first group (n = 36) were treated with edaravone 30 mg twice a day intravenously. Neuroprotectors were not used in the control group (n = 12). Clinical-instrumental and neurological examination (Glasgow scale (SCG), FOUR, NIHSS, and neuronspecific enolase (NSE) levels) were performed on all patients. Results The mean FOUR score in the 1th group increased from 11.04±0.85 to 15.47±0.63 points against 11.39±0.56 to 13.46±1.49 in the control group (pp<0.05). The level of NSE in control group patients increased 10-fold (from 9.2 to 96.4 ng/ml, p<0.01). Subsequently, there was a rapid decrease in NSE level in 1th group, and in the control group until 10 days of treatment, the level of NSE did not reach the reference values (p p<0.05). Conclusions The introduction of edaravone in women with AIS results in positive results already in the acute period of the disease. The use of edaravon was significantly effective on the FOUR scale and the dynamics of NSE levels. Conclusions The introduction of edaravone in women with AIS results in positive results already in the acute period of the disease. The use of edaravon was significantly effective on the FOUR scale and the dynamics of NSE levels. The aim To research differences of interleukin (IL)-17 and IL-23 serum levels in patients with Alzheimer's disease, vascular dementia and mild cognitive impairment. Material and methods Serum levels of IL-17 and IL-23 were measure by ELISA for 15 patients with Alzheimer's disease, 14 with vascular dementia, 30 with mild cognitive impairment and 30 control individuals without cognitive impairment. Results Serum concentrations of IL-17 were significantly higher in Alzheimer's disease patients (P=0.0023) than control, in vascular dementia no significant differences(P=0.4154). Level of IL-23 was significantly higher than control in Alzheimer's disease patients (P=0.0170) and vascular dementia (P=0.0002), but in Alzheimer's disease it was in 12.5 time higher. In total mild cognitive impairment patients no significant differences in interleukin concentration with control, but significant differences observed for amnestic form in IL-17 (P=0.0436) and IL-23 (P=0.0019). Conclusions IL-17 and IL-23 level significant higher in Alzheimer's disease patients compared with control and vascular dementia.