Water pollution from heavy metals and their toxic oxo-anionic derivatives such as CrO42-, Cr2O72-, HAsO42-, and HAsO32- has become one of the most critical environmental issues. To address this, herein, we report a new hydrolytically stable luminescent Zn(ii) based cationic metal organic framework (MOF), iMOF-4C, which further successfully exhibited a rare dual "turn off/on" fluorescence response toward Cr(vi), As(v) and As(iii) based oxo-anions respectively in water medium. In addition, iMOF-4C was found to maintain its superior selectivity in the presence of other concurrent anions (e.g. SO42-, Cl-, Br-, ClO4-, NO3-, SCN- and CO32-). More importantly, iMOF-4C exhibited an excellent selective and sensitive luminescence "turn-off" response towards CrO42- and Cr2O72- anions in water medium with the quenching constant (Ksv) values as high as 1.31 × 105 M-1 (CrO42-) and 4.85 × 105 M-1 (Cr2O72-), which are found to be the highest among the values reported in the regime of MOFs. Interestingly, iMOF-4C showed fluorescence "turn-on" response toward HAsO42- and HAsO32- with an enhancement coefficient (Kec) of 1.98 × 104 M-1 and 3.56 × 103 M-1 respectively. The high sensitivity and low detection limits make iMOF-4C more feasible for real-time sensing of such toxic oxo-anions in an aqueous medium. Furthermore, the probable sensing mechanism has been investigated by DFT calculation studies and discussed in detail.We present a label-free approach that is based on tip-enhanced Raman spectroscopy (TERS) for a direct in situ assessment of the molecular reactivity in plasmon-driven reactions. Using this analytical approach, named cargo-TERS, we investigate the relationship between the chemical structure of aromatic halides and the catalytic probability of the Suzuki-Miyaura coupling reaction on gold-palladium bimetallic nanoplates (Au@PdNPs). We demonstrate that cargo-TERS can be used to quantify the yield of biphenyl-4,4'-dithiol (BPDT), the product of the coupling reaction. Our results also show that the halide reactivity decreases from bromo through chloro to fluorohalides. Finally, we employ this novel imaging technique to unravel the nanoscale reactivity and selectivity of Au@PdNPs. We find that the edges and corners of these nanostructures exhibit the highest catalytic reactivity, while the flat terraces of Au@PdNPs remain catalytically inactive.We employ a single optically trapped upconverting nanoparticle (UCNP) of NaYF4Yb,Er of diameter about 100 nm as a subdiffractive source to perform absorption spectroscopy. The experimentally expected mode volume of 100 nm of the backscatter profile of the nanoparticle matches well with a numerical simulation of the dominant backscattering modes to confirm our assertion of achieving a source dimension considerably lower than the diffraction limit set by the excitation wavelength of 975 nm for the UCNP. We perform absorption spectroscopy of several diverse entities such as the dye Rhodamine B in water, a thin gold film of thickness 30 nm, and crystalline soft oxometalates micro-patterned on a glass substrate using the UCNP as a source. The initial results lead to unambiguous utility of UCNPs as single nanoscopic sources for absorption spectroscopy of ultra-small sample volumes (femtolitres), and lead us to hypothesize a possible Resonance Energy Transfer mechanism between the UCNP and the molecules of the ambient medium, which may even lead to single molecule absorption spectroscopy applications.The surface topography of engineered extracellular matrices is one of the most important physical cues regulating the phenotypic polarization of macrophages. However, not much is known about the ways through which submicron (i.e., 100-1000 nm) topographies modulate the polarization of macrophages. In the context of bone tissue regeneration, it is well established that this range of topographies stimulates the osteogenic differentiation of stem cells. Since the immune response affects the bone tissue regeneration process, the immunomodulatory consequences of submicron patterns should be studied prior to their clinical application. Here, we 3D printed submicron pillars (using two-photon polymerization technique) with different heights and interspacings to perform the first ever systematic study of such effects. Among the studied patterns, the highest degree of elongation was observed for the cells cultured on those with the tallest and densest pillars. After 3 days of culture with inflammatory stimuli (LPS/IFN-γ), sparsely decorated surfaces inhibited the expression of the pro-inflammatory cellular marker CCR7 as compared to day 1 and to the other patterns. Furthermore, sufficiently tall pillars polarized the M1 macrophages towards a pro-healing (M2) phenotype, as suggested by the expression of CD206 within the first 3 days. As some of the studied patterns are known to be osteogenic, the osteoimmunomodulatory capacity of the patterns should be further studied to optimize their bone tissue regeneration performance.A Pd(ii)-catalyzed oxidative alkenylation of 4-hydroxycoumarins with maleimides for the synthesis of 4-hydroxy-3-maleimidecoumarins has been described. This methodology proceeds via C-H activation and C(sp2)-C(sp2) bond formation providing a series of alkenylated Heck-type products.The walnut protein hydrolysate (WPH) was prepared via simulated gastrointestinal digestion. The degree of hydrolysis (DH), amino acid composition, and relative molecular weight distribution of WPH were analyzed. The results showed that the DH of WPH was 11.6%, WPH was rich in Glu and Pro, and the relative average molecular weight of 572 Da accounted for 59.78%. The effects of WPH on osteoporosis were evaluated using a model of retinoic acid-induced osteoporosis rat. Treatment with WPH effectively increased the serum calcium and phosphorus contents, alleviated calcium loss, and reduced tartrate-resistant acid phosphate and alkaline phosphatase activities and bone gla protein content. WPH treatment significantly improved the biomechanical properties of the bone and increased the value of bone mineral density. In addition, WPH treatment improved the bone microstructure. https://www.selleckchem.com/products/wortmannin.html WPH was isolated and purified by Sephadex G-25 gel filtration chromatography and semi-preparative reversed-phase high-performance liquid chromatography.