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- Microbiome Profiling by Sequencing: Definitions and TechnologiesMicroorganisms are ubiquitous in all kinds of environments on earth – they live in soil, water, inside or on the surface of animals and plants, and can even survive in extreme conditions. Microbiomics is the systematic study of the cohort of microorganisms in a given environment. With the advent of various sequencing technologies, researchers can finally get the whole picture of...0 Commentarios 0 Acciones 17 Views 0 Vista previaPlease log in to like, share and comment!
- Targeting RNA Splicing: Mechanisms and StrategiesWhat Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that...0 Commentarios 0 Acciones 16 Views 0 Vista previa
- Decoding the Role of Chimeric RNA in Cellular ProcessesWhat is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse...0 Commentarios 0 Acciones 25 Views 0 Vista previa
- A Comparative Analysis of Prime Editing and CRISPR-Cas9What is CRISPR-Cas9? CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of a guide RNA (gRNA) and a Cas9 protein. The gRNA is designed to complement specific target sequences in the...0 Commentarios 0 Acciones 24 Views 0 Vista previa
- Variant Analysis Workflow in BioinformaticsIntroduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. Variant detection and analysis refer to the sequencing and difference...0 Commentarios 0 Acciones 22 Views 0 Vista previa
- Whole Virus Genome Sequencing in Screening New DrugsWhole genome sequencing of viruses is playing an increasingly important role in clinical practice. On the one hand, analyzing the drug resistance information of the virus can assist in more accurate clinical diagnosis, treatment, and disease course management; On the other hand, through the establishment of molecular epidemiology of the virus, strict control of viral infection can...0 Commentarios 0 Acciones 24 Views 0 Vista previa
- Pan-Cancer Analysis Uncovers Structural Variants as Vital Contributors to Tumor NeoantigensWithin the tumor genome, somatic mutations hold the ability to yield altered proteins that trigger immune responses against tumors. These mutated proteins fragment into peptides and are showcased on major histocompatibility complex (MHC) molecules. These distinct peptides, coined as "neoantigens," play a pivotal role in anti-tumor immune activity and have emerged as promising targets for...0 Commentarios 0 Acciones 47 Views 0 Vista previa
- WGBS Reveals the Dynamic DNA Methylation Turnover in PlantIn some eukaryotes, DNA methylation occurs in the coding regions of genes and is called gene body methylation (GbM). Although the role of DNA methylation in transposon and repetitive DNA silencing has been well characterized, gene body methylation is not associated with transcriptional repression, and its biological importance is unknown. WGBS Service Whole genome bisulfite...0 Commentarios 0 Acciones 49 Views 0 Vista previa
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